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Dorsal hippocampus contributes to model-based planning

Nature neuroscience, 2017-09, Vol.20 (9), p.1269-1276 [Peer Reviewed Journal]

COPYRIGHT 2017 Nature Publishing Group ;COPYRIGHT 2017 Nature Publishing Group ;Copyright Nature Publishing Group Sep 2017 ;ISSN: 1097-6256 ;EISSN: 1546-1726 ;DOI: 10.1038/nn.4613 ;PMID: 28758995

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Title:
Dorsal hippocampus contributes to model-based planning
Author: Miller, Kevin J ; Botvinick, Matthew M ; Brody, Carlos D
Subjects: Animal experimentation ; Animals ; Behavior, Animal - drug effects ; Behavior, Animal - physiology ; Brain ; Clinical trials ; Damage ; Deactivation ; Exploratory Behavior - drug effects ; Exploratory Behavior - physiology ; GABA-A Receptor Agonists - toxicity ; Hippocampus ; Hippocampus (Brain) ; Hippocampus - drug effects ; Hippocampus - pathology ; Hippocampus - physiology ; Inactivation ; Male ; Management ; Methods ; Muscimol ; Muscimol - toxicity ; Photic Stimulation - methods ; Physiological aspects ; Rats ; Rats, Long-Evans ; Recognition, Psychology - drug effects ; Recognition, Psychology - physiology ; Rodents
Is Part Of: Nature neuroscience, 2017-09, Vol.20 (9), p.1269-1276
Description: Planning can be defined as action selection that leverages an internal model of the outcomes likely to follow each possible action. Its neural mechanisms remain poorly understood. Here we adapt recent advances from human research for rats, presenting for the first time an animal task that produces many trials of planned behavior per session, making multitrial rodent experimental tools available to study planning. We use part of this toolkit to address a perennially controversial issue in planning: the role of the dorsal hippocampus. Although prospective hippocampal representations have been proposed to support planning, intact planning in animals with damaged hippocampi has been repeatedly observed. Combining formal algorithmic behavioral analysis with muscimol inactivation, we provide causal evidence directly linking dorsal hippocampus with planning behavior. Our results and methods open the door to new and more detailed investigations of the neural mechanisms of planning in the hippocampus and throughout the brain.
Publisher: United States: Nature Publishing Group
Language: English
Identifier: ISSN: 1097-6256
EISSN: 1546-1726
DOI: 10.1038/nn.4613
PMID: 28758995
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

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Dorsal hippocampus contributes to model-based planning

COPYRIGHT 2017 Nature Publishing Group ;COPYRIGHT 2017 Nature Publishing Group ;Copyright Nature Publishing Group Sep 2017 ;ISSN: 1097-6256 ;EISSN: 1546-1726 ;DOI: 10.1038/nn.4613 ;PMID: 28758995

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