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Data sharing and reanalysis of randomized controlled trials in leading biomedical journals with a full data sharing policy: survey of studies published in The BMJ and PLOS Medicine

BMJ, 2018-02, Vol.360, p.k400-k400 [Peer Reviewed Journal]

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to ;Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. ;Copyright: 2018 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions ;Distributed under a Creative Commons Attribution 4.0 International License ;Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to 2018 BMJ ;ISSN: 0959-8138 ;EISSN: 1756-1833 ;EISSN: 1468-5833 ;DOI: 10.1136/bmj.k400 ;PMID: 29440066

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  • Title:
    Data sharing and reanalysis of randomized controlled trials in leading biomedical journals with a full data sharing policy: survey of studies published in The BMJ and PLOS Medicine
  • Author: Naudet, Florian ; Sakarovitch, Charlotte ; Janiaud, Perrine ; Cristea, Ioana ; Fanelli, Daniele ; Moher, David ; Ioannidis, John P A
  • Subjects: Clinical trials ; Data Accuracy ; Evidence-based medicine ; Humans ; Information Dissemination ; Information sharing ; Labelling ; Life Sciences ; Medical research ; Medicine ; Open access ; Periodicals as Topic - statistics & numerical data ; Randomized Controlled Trials as Topic - statistics & numerical data ; Science
  • Is Part Of: BMJ, 2018-02, Vol.360, p.k400-k400
  • Description: AbstractObjectivesTo explore the effectiveness of data sharing by randomized controlled trials (RCTs) in journals with a full data sharing policy and to describe potential difficulties encountered in the process of performing reanalyses of the primary outcomes.DesignSurvey of published RCTs.SettingPubMed/Medline.Eligibility criteriaRCTs that had been submitted and published by The BMJ and PLOS Medicine subsequent to the adoption of data sharing policies by these journals.Main outcome measureThe primary outcome was data availability, defined as the eventual receipt of complete data with clear labelling. Primary outcomes were reanalyzed to assess to what extent studies were reproduced. Difficulties encountered were described.Results37 RCTs (21 from The BMJ and 16 from PLOS Medicine) published between 2013 and 2016 met the eligibility criteria. 17/37 (46%, 95% confidence interval 30% to 62%) satisfied the definition of data availability and 14 of the 17 (82%, 59% to 94%) were fully reproduced on all their primary outcomes. Of the remaining RCTs, errors were identified in two but reached similar conclusions and one paper did not provide enough information in the Methods section to reproduce the analyses. Difficulties identified included problems in contacting corresponding authors and lack of resources on their behalf in preparing the datasets. In addition, there was a range of different data sharing practices across study groups.ConclusionsData availability was not optimal in two journals with a strong policy for data sharing. When investigators shared data, most reanalyses largely reproduced the original results. Data sharing practices need to become more widespread and streamlined to allow meaningful reanalyses and reuse of data.Trial registrationOpen Science Framework osf.io/c4zke.
  • Publisher: England: BMJ Publishing Group LTD
  • Language: English
  • Identifier: ISSN: 0959-8138
    EISSN: 1756-1833
    EISSN: 1468-5833
    DOI: 10.1136/bmj.k400
    PMID: 29440066
  • Source: BMJ Journals (Open Access)
    AUTh Library subscriptions: ProQuest Central
    MEDLINE
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