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Vaccines against enteric infections for the developing world

Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2015-06, Vol.370 (1671), p.20150142-20150142 [Peer Reviewed Journal]

2015 The Author(s) Published by the Royal Society. All rights reserved. ;2015 The Author(s) Published by the Royal Society. All rights reserved. 2015 ;ISSN: 0962-8436 ;EISSN: 1471-2970 ;DOI: 10.1098/rstb.2015.0142 ;PMID: 25964464

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Title:
Vaccines against enteric infections for the developing world
Author: Czerkinsky, Cecil ; Holmgren, Jan
Subjects: Adjuvants, Immunologic ; ANTIBODY-RESPONSES ; Bacterial Infections - epidemiology ; Bacterial Infections - prevention & control ; Biological Sciences ; Biologiska vetenskaper ; Biology ; CELL RESPONSES ; Child, Preschool ; CONTROLLED-TRIAL ; Developing Country ; DEVELOPING-COUNTRIES ; EFFICACY TRIAL ; Enteric ; Gut ; Humans ; Immunity ; INACTIVATED POLIOVIRUS VACCINE ; Infant ; Infant, Newborn ; Intestinal Diseases - epidemiology ; Intestinal Diseases - prevention & control ; Mucosa ; MUCOSAL ; ORAL CHOLERA VACCINES ; Review ; ROTAVIRUS VACCINATION ; TYPHOID-FEVER ; Vaccine ; Vaccines - immunology ; Virus Diseases - epidemiology ; Virus Diseases - prevention & control
Is Part Of: Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2015-06, Vol.370 (1671), p.20150142-20150142
Description: Since the first licensure of the Sabin oral polio vaccine more than 50 years ago, only eight enteric vaccines have been licensed for four disease indications, and all are given orally. While mucosal vaccines offer programmatically attractive tools for facilitating vaccine deployment, their development remains hampered by several factors: —limited knowledge regarding the properties of the gut immune system during early life; —lack of mucosal adjuvants, limiting mucosal vaccine development to live-attenuated or killed whole virus and bacterial vaccines; —lack of correlates/surrogates of mucosal immune protection; and —limited knowledge of the factors contributing to oral vaccine underperformance in children from developing countries. There are now reasons to believe that the development of safe and effective mucosal adjuvants and of programmatically sound intervention strategies could enhance the efficacy of current and next-generation enteric vaccines, especially in lesser developed countries which are often co-endemic for enteric infections and malnutrition. These vaccines must be safe and affordable for the world's poorest, confer long-term protection and herd immunity, and must be able to contain epidemics.
Publisher: England: The Royal Society
Language: English
Identifier: ISSN: 0962-8436
EISSN: 1471-2970
DOI: 10.1098/rstb.2015.0142
PMID: 25964464
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central

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Vaccines against enteric infections for the developing world

2015 The Author(s) Published by the Royal Society. All rights reserved. ;2015 The Author(s) Published by the Royal Society. All rights reserved. 2015 ;ISSN: 0962-8436 ;EISSN: 1471-2970 ;DOI: 10.1098/rstb.2015.0142 ;PMID: 25964464

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