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Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges

Nature immunology, 2014-10, Vol.15 (10), p.895-899 [Peer Reviewed Journal]

COPYRIGHT 2014 Nature Publishing Group ;COPYRIGHT 2014 Nature Publishing Group ;Copyright Nature Publishing Group Oct 2014 ;Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2014. ;ISSN: 1529-2908 ;EISSN: 1529-2916 ;DOI: 10.1038/ni.2961 ;PMID: 25232810

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Title:
Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges
Author: Aaby, Peter ; Kollmann, Tobias R ; Benn, Christine Stabell
Subjects: Care and treatment ; Female ; Humans ; Immune response ; Infant ; Infant, Newborn ; Infants ; Male ; Medical research ; Medicine, Experimental ; Neonates ; Outcome Assessment (Health Care) - trends ; Physiological aspects ; Practice Guidelines as Topic ; Preventive Medicine - methods ; Preventive Medicine - standards ; Preventive Medicine - trends ; Public health ; Public Health - methods ; Public Health - standards ; Public Health - trends ; Testing ; Vaccination ; Vaccination - methods ; Vaccination - standards ; Vaccination - trends ; Vaccines ; Vaccines - administration & dosage ; Vaccines - immunology ; World Health Organization
Is Part Of: Nature immunology, 2014-10, Vol.15 (10), p.895-899
Description: Vaccines can have nonspecific effects through their modulation of responses to infections not specifically targeted by the vaccine. However, lack of knowledge about the underlying immunological mechanisms and molecular cause-and-effect relationships prevent use of this potentially powerful early-life intervention to its greatest benefit. The World Health Organization has identified investigations into the molecular basis of nonspecific vaccine effects as a research priority.
Publisher: United States: Nature Publishing Group
Language: English
Identifier: ISSN: 1529-2908
EISSN: 1529-2916
DOI: 10.1038/ni.2961
PMID: 25232810
Source: MEDLINE
ProQuest Central

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Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges

COPYRIGHT 2014 Nature Publishing Group ;COPYRIGHT 2014 Nature Publishing Group ;Copyright Nature Publishing Group Oct 2014 ;Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2014. ;ISSN: 1529-2908 ;EISSN: 1529-2916 ;DOI: 10.1038/ni.2961 ;PMID: 25232810

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