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Biocatalytic production of Ɛ-caprolactone using Geotrichum candidum cells immobilized on functionalized silica

Applied microbiology and biotechnology, 2020-10, Vol.104 (20), p.8887-8895 [Peer Reviewed Journal]

Springer-Verlag GmbH Germany, part of Springer Nature 2020 ;ISSN: 0175-7598 ;EISSN: 1432-0614 ;DOI: 10.1007/s00253-020-10875-7 ;PMID: 32902680

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  • Title:
    Biocatalytic production of Ɛ-caprolactone using Geotrichum candidum cells immobilized on functionalized silica
  • Author: Silva, André Leonardo Patrício ; da Silva Caridade, Taiza Nayara ; Magalhães, Renata Rodrigues ; de Sousa, Kelly Teotonio ; de Sousa, Christian Carlos ; Vale, Juliana Alves
  • Subjects: Applied Microbial and Cell Physiology ; Biomedical and Life Sciences ; Biotechnology ; Caproates ; Geotrichum ; Lactones ; Life Sciences ; Microbial Genetics and Genomics ; Microbiology ; Silicon Dioxide
  • Is Part Of: Applied microbiology and biotechnology, 2020-10, Vol.104 (20), p.8887-8895
  • Description: Immobilization of the Geotrichum candidum (CCT 1205) cell with functionalized silica creates promising biocatalysts for production of ɛ-caprolactone. The results obtained by immobilization of the whole cell on SiO 2 -NH 2 and SiO 2 -SH supports indicate that the presence of reactive functional groups on the support may promote effective chemical bonds with the cell walls resulting the decreased dehydrogenases enzyme activity (5% yield in less than 2h) and consequently, increased Baeyer-Villiger monooxygenases enzyme activity with redacting of 25% of time reaction when is used SiO 2 -NH 2 as support and 50% through use of SiO 2 -SH as support relative to free cells when cyclohexanone is used as a substrate. The catalysts SiO 2 –NH 2 –Geotrichum candidum and SiO 2 –SH –Geotrichum candidum were recycling and reused in the ɛ-caprolactone synthesis from cyclohexanone, and the biocatalysts promoted a quantitative conversion up to the eighth reaction cycle. Key points • Immobilized microorganism is more efficient than free cell in the caprolactone synthesis. • The reaction times for amino and thiol groups in support were 3 h and 2 h, respectively. • These catalysts showed higher ɛ-caprolactone conversion at higher concentrations.
  • Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
  • Language: English
  • Identifier: ISSN: 0175-7598
    EISSN: 1432-0614
    DOI: 10.1007/s00253-020-10875-7
    PMID: 32902680
  • Source: MEDLINE
    ProQuest Central
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