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Biodistribution of Insulin Following Massive Insulin Subcutaneous Injection: A Case Report

Internal Medicine, 2022, pp.7364-21 [Peer Reviewed Journal]

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Title:
Biodistribution of Insulin Following Massive Insulin Subcutaneous Injection: A Case Report
Author: Ikeda, Tomoya ; Tani, Naoto ; Hirokawa, Tatsuya ; Ikeda, Kei ; Morioka, Fumiya ; Shida, Alissa ; Aoki, Yayoi ; Ishikawa, Takaki
Subjects: Blood concentration ; Insulin injection ; Pulmonary edema ; Tissue concentration, Glucose
Is Part Of: Internal Medicine, 2022, pp.7364-21
Description: A man in his 30s injected insulin several times into his abdomen and was found dead several hours later. Micropathological findings showed alveolar injury with hemorrhaging and cerebral parietal lobe nerve cell edema. Biochemical examinations showed that the blood insulin level was high, significantly so at the insulin injection sites. The blood glucose and C-peptide levels were low. The insulin level in the kidneys was low. In forensic medicine, a postmortem diagnosis of insulin subcutaneous injection is often difficult. When insulin injection is suspected, particularly high insulin levels can be expected at the insulin injection site, rather than in the blood.
Publisher: Japan: The Japanese Society of Internal Medicine
Language: English
Identifier: ISSN: 0918-2918
EISSN: 1349-7235
DOI: 10.2169/internalmedicine.7364-21
PMID: 35283372
Source: PubMed Central
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