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Organoids of the female reproductive tract

Journal of molecular medicine (Berlin, Germany), 2021-04, Vol.99 (4), p.531-553 [Peer Reviewed Journal]

The Author(s) 2021 ;The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 0946-2716 ;EISSN: 1432-1440 ;DOI: 10.1007/s00109-020-02028-0 ;PMID: 33580825

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Title:
Organoids of the female reproductive tract
Author: Chumduri, Cindrilla ; Turco, Margherita Y.
Subjects: Animals ; Biomedical and Life Sciences ; Biomedicine ; Cervix ; CRISPR-Cas Systems ; Drug Discovery - methods ; Estrous Cycle - physiology ; Extracellular Matrix - physiology ; Female ; Fertility ; Gametes ; Gene Editing - methods ; Gene Editing - trends ; Genital Diseases, Female - pathology ; Genital Diseases, Female - therapy ; Genitalia, Female - anatomy & histology ; Genitalia, Female - cytology ; Genitalia, Female - physiology ; Gestational Age ; Gonadal Steroid Hormones - physiology ; Human Genetics ; Humans ; Internal Medicine ; Maternal-Fetal Exchange ; Menstrual cycle ; Menstruation ; Mice ; Molecular Medicine ; Mucosa ; Organoids ; Organoids - cytology ; Pituitary Hormones, Anterior - physiology ; Placenta - cytology ; Precision Medicine - methods ; Precision Medicine - trends ; Pregnancy ; Reproductive system ; Review ; Stem Cells - cytology ; Tissue Engineering - methods ; Tissue Engineering - trends ; Uterus ; Vagina
Is Part Of: Journal of molecular medicine (Berlin, Germany), 2021-04, Vol.99 (4), p.531-553
Description: Healthy functioning of the female reproductive tract (FRT) depends on balanced and dynamic regulation by hormones during the menstrual cycle, pregnancy and childbirth. The mucosal epithelial lining of different regions of the FRT—ovaries, fallopian tubes, uterus, cervix and vagina—facilitates the selective transport of gametes and successful transfer of the zygote to the uterus where it implants and pregnancy takes place. It also prevents pathogen entry. Recent developments in three-dimensional (3D) organoid systems from the FRT now provide crucial experimental models that recapitulate the cellular heterogeneity and physiological, anatomical and functional properties of the organ in vitro. In this review, we summarise the state of the art on organoids generated from different regions of the FRT. We discuss the potential applications of these powerful in vitro models to study normal physiology, fertility, infections, diseases, drug discovery and personalised medicine.
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
Language: English
Identifier: ISSN: 0946-2716
EISSN: 1432-1440
DOI: 10.1007/s00109-020-02028-0
PMID: 33580825
Source: SpringerOpen
AUTh Library subscriptions: ProQuest Central
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Organoids of the female reproductive tract

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