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Brain immunology and immunotherapy in brain tumours

Nature reviews. Cancer, 2020-01, Vol.20 (1), p.12-25 [Peer Reviewed Journal]

COPYRIGHT 2020 Nature Publishing Group ;COPYRIGHT 2020 Nature Publishing Group ;Copyright Nature Publishing Group Jan 2020 ;ISSN: 1474-175X ;EISSN: 1474-1768 ;DOI: 10.1038/s41568-019-0224-7 ;PMID: 31806885

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Title:
Brain immunology and immunotherapy in brain tumours
Author: Sampson, John H ; Gunn, Michael D ; Fecci, Peter E ; Ashley, David M
Subjects: Animals ; Biomarkers, Tumor ; Blood-Brain Barrier - metabolism ; Brain - immunology ; Brain - metabolism ; Brain cancer ; Brain Neoplasms - etiology ; Brain Neoplasms - metabolism ; Brain Neoplasms - pathology ; Brain Neoplasms - therapy ; Brain tumors ; Central nervous system ; Clinical Trials as Topic ; Combined Modality Therapy ; Disease Management ; Disease Susceptibility ; Genetics ; Glioma ; Gliomas ; Heterogeneity ; Humans ; Immune system ; Immunity ; Immunology ; Immunomodulation ; Immunotherapy ; Standard of Care ; Treatment Outcome ; Tumor Microenvironment ; Tumors
Is Part Of: Nature reviews. Cancer, 2020-01, Vol.20 (1), p.12-25
Description: Gliomas, the most common malignant primary brain tumours, remain universally lethal. Yet, seminal discoveries in the past 5 years have clarified the anatomy, genetics and function of the immune system within the central nervous system (CNS) and altered the paradigm for successful immunotherapy. The impact of standard therapies on the response to immunotherapy is now better understood, as well. This new knowledge has implications for a broad range of tumours that develop within the CNS. Nevertheless, the requirements for successful therapy remain effective delivery and target specificity, while the dramatic heterogeneity of malignant gliomas at the genetic and immunological levels remains a profound challenge.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1474-175X
EISSN: 1474-1768
DOI: 10.1038/s41568-019-0224-7
PMID: 31806885
Source: AUTh Library subscriptions: ProQuest Central
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Brain immunology and immunotherapy in brain tumours

COPYRIGHT 2020 Nature Publishing Group ;COPYRIGHT 2020 Nature Publishing Group ;Copyright Nature Publishing Group Jan 2020 ;ISSN: 1474-175X ;EISSN: 1474-1768 ;DOI: 10.1038/s41568-019-0224-7 ;PMID: 31806885

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