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Feasibility, safety and oncological short-term outcome of laparoscopic pancreaticoduodenectomy for periampullary cancer: Findings from a large sample from Vietnam

Medicine (Baltimore), 2024-04, Vol.103 (15), p.e37769-e37769 [Peer Reviewed Journal]

Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc. ;Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc. 2024 ;ISSN: 0025-7974 ;EISSN: 1536-5964 ;DOI: 10.1097/MD.0000000000037769 ;PMID: 38608081

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  • Title:
    Feasibility, safety and oncological short-term outcome of laparoscopic pancreaticoduodenectomy for periampullary cancer: Findings from a large sample from Vietnam
  • Author: Pham, Hai Minh ; Le Quan, Anh Tuan ; Nguyen, Bac Hoang
  • Subjects: Aged ; Duodenal Neoplasms ; Feasibility Studies ; Female ; Humans ; Laparoscopy - adverse effects ; Male ; Middle Aged ; Observational Study ; Pancreatic Fistula ; Pancreaticoduodenectomy - adverse effects ; Prospective Studies ; Vietnam - epidemiology
  • Is Part Of: Medicine (Baltimore), 2024-04, Vol.103 (15), p.e37769-e37769
  • Description: Laparoscopic pancreaticoduodenectomy (LPD) is an alternative to open pancreaticoduodenectomy (OPD) for treatment of periampullary cancer in selected patients. However, this is a difficult procedure with a high complication rate. We conducted a prospective cohort study of 85 patients with suspected periampullary cancer who underwent LPD from February 2017 to January 2022 at University Medical Center at Ho Chi Minh City, Vietnam. Among these, 15 patients were excluded from the data analysis because of benign disease confirmed by postoperative pathological examination. Among 70 patients, the mean age was 58.9 ± 8.9 years old and 51.4% were female. The conversion rate to open surgery was 7.1% (n = 5). Among those underwent LPD, the mean operating time and estimated blood loss were 509 ± 94 minutes and 267 ± 102 mL, respectively. The median length of hospital stay was 8 days, interquartile range (IQR) 7-12 days. The percentage of cumulative morbidity, pancreatic fistula and major complication was 35.4%, 12.3%, and 13.8%, respectively. The median of comprehensive complication index (CCI) was 26.2 (IQR 20.9-29.6). Three patients required reoperation due to severe pancreatic fistula (n = 2) and necrotizing pancreatitis (n = 1). There was no death after ninety-day. The average number of harvested lymph nodes was 16.6 ± 5.1. The percentage of R0 resection was 100%. With properly selected patients, LPD can be a feasible, safe and effective approach with acceptable short-term outcomes.
  • Publisher: United States: Lippincott Williams & Wilkins
  • Language: English
  • Identifier: ISSN: 0025-7974
    EISSN: 1536-5964
    DOI: 10.1097/MD.0000000000037769
    PMID: 38608081
  • Source: IngentaConnect Open Access
    Journals@Ovid Open Access Journal Collection Rolling
    MEDLINE
    PubMed Central
    Wolters Kluwer Open Access
    DOAJ Directory of Open Access Journals
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