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Factors Influencing Diagnostic Success of Computed Tomography-guided Transthoracic Needle Biopsy in Intrathoracic Lesions: An Experience of a Reference Chest Disease Hospital

Istanbul medical journal, 2023-02, Vol.24 (1), p.14-21 [Peer Reviewed Journal]

COPYRIGHT 2023 Galenos Yayinevi Tic. Ltd. ;2023. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 2619-9793 ;ISSN: 1304-8503 ;EISSN: 2148-094X ;DOI: 10.4274/imj.galenos.2022.00194

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  • Title:
    Factors Influencing Diagnostic Success of Computed Tomography-guided Transthoracic Needle Biopsy in Intrathoracic Lesions: An Experience of a Reference Chest Disease Hospital
  • Author: Abalı, Hülya ; Şimşek Veske, Nurdan ; Uslu, Berat ; Tokgöz Akyıl, Fatma ; Tural Önür, Seda
  • Subjects: Analysis ; Biopsy ; Cardiovascular agents ; Cardiovascular disease ; Chronic illnesses ; Chronic obstructive pulmonary disease ; complications ; CT imaging ; ct-guided ; diagnostic success ; Drugs ; Embolisms ; Hemorrhage ; Lung cancer ; Medical diagnosis ; Medical research ; Medicine, Experimental ; Pathology ; Patients ; PET imaging ; Pneumothorax ; Success ; suvmax ; Thoracic surgery ; Tomography ; transthoracic biopsy ; Tuberculosis
  • Is Part Of: Istanbul medical journal, 2023-02, Vol.24 (1), p.14-21
  • Description: Introduction: Transthoracic needle biopsy (TNB) is a common, safe and inexpensive procedure used in the diagnosis of intrathoracic lesions. Until today, there is still no study about the influence of standardized uptake value (SUVmax) in positron emission tomography/computed tomography (PET/CT) on the diagnostic success of TNB in intrathoracic lesions. We aimed to analyze the factors, one of which was the SUVmax value influencing the diagnosis success of CT-guided TNB in pulmonary, mediastinal and pleural lesions. Secondary aim was to investigate the predictive clinical factors of complications. Methods: A retrospective study of 403 patients who underwent CT-guided TNB at a reference chest diseases hospital between February 2019 and February 2021 was conducted. A pulmonologist had performed the procedure with a 20-gauge fine-needle (Spinal) or a 14-gauge automated needle (tru-cut). Data of pathology, microbiology and clinical follow-up of the patients were collected. A chi-square and Student’s t-test were used to evaluate the patient-related factors (gender and smoking), lesion-related factors (type, side, location, size, presence of necrosis observed by CT, SUVmax value in PET/CT), and procedure factor (type of needle) on the diagnostic success. Additionally, associations between clinical characteristics of patients and the complications were assessed. Results: A total of 403 patients underwent CT-guided TNB were enrolled and overall success was 70% (284/403). Smoking history (75% vs 43%, p=0.02) was predictor for diagnostic success. Lesion size and SUVmax value were significantly high in diagnosed patients (for both p<0.001). Diagnostic success was high in peripheral and central lesions, more notably in central lesions (p=0.004, p=0.016, respectively). The 9.2 SUVmax cut-off value had sensitivity of 79%, specificity of %53, success of 79% (p<0.01). Cardiovascular diseases, anti-coagulants, vitamin K antagonists, and salicylate induced complications (p=0.031, p=0.022, p=0.011, p=0.04, respectively). Low-molecular-weight-heparin was associated with hemorrhage (p=0.016). Conclusion: We observed that type, size and SUVmax value of lesion and smoking status were the predictive factors for a diagnostic biopsy.
  • Publisher: Istanbul: Galenos Yayinevi Tic. Ltd
  • Language: English;Turkish
  • Identifier: ISSN: 2619-9793
    ISSN: 1304-8503
    EISSN: 2148-094X
    DOI: 10.4274/imj.galenos.2022.00194
  • Source: DOAJ : Directory of Open Access Journals
    AUTh Library subscriptions: ProQuest Central
    ROAD
    Coronavirus Research Database
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