skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Mitochondrial Mechanisms in Diabetic Cardiomyopathy

Diabetes & metabolism journal, 2020-02, Vol.44 (1), p.33-53 [Peer Reviewed Journal]

COPYRIGHT(C) KYOBO BOOK CENTRE ALL RIGHTS RESERVED ;ISSN: 2233-6079 ;EISSN: 2233-6087

Full text available

Citations Cited by
  • Title:
    Mitochondrial Mechanisms in Diabetic Cardiomyopathy
  • Author: Johannes Gollmer ; Andreas Zirlik ; Heiko Bugger
  • Subjects: Diabetes mellitus ; Diabetic cardiomyopathies ; Heart failure ; Mitochondria
  • Is Part Of: Diabetes & metabolism journal, 2020-02, Vol.44 (1), p.33-53
  • Description: Mitochondrial medicine is increasingly discussed as a promising therapeutic approach, given that mitochondrial defects are thought to contribute to many prevalent diseases and their complications. In individuals with diabetes mellitus (DM), defects in mitochondrial structure and function occur in many organs throughout the body, contributing both to the pathogenesis of DM and complications of DM. Diabetic cardiomyopathy (DbCM) is increasingly recognized as an underlying cause of increased heart failure in DM, and several mitochondrial mechanisms have been proposed to contribute to the development of DbCM. Well established mechanisms include myocardial energy depletion due to impaired adenosine triphosphate (ATP) synthesis and mitochondrial uncoupling, and increased mitochondrial oxidative stress. A variety of upstream mechanisms of impaired ATP regeneration and increased mitochondrial reactive oxygen species have been proposed, and recent studies now also suggest alterations in mitochondrial dynamics and autophagy, impaired mitochondrial Ca 2+ uptake, decreased cardiac adiponectin action, increased O-GlcNAcylation, and impaired activity of sirtuins to contribute to mitochondrial defects in DbCM, among others. In the current review, we present and discuss the evidence that underlies both established and recently proposed mechanisms that are thought to contribute to mitochondrial dysfunction in DbCM.
  • Publisher: 대한당뇨병학회
  • Language: Korean
  • Identifier: ISSN: 2233-6079
    EISSN: 2233-6087
  • Source: KoreaMed (Open access)
    Open Access: PubMed Central
    KoreaMed Synapse(OpenAccess)
    Directory of Open Access Journals
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait