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Climbing fibers encode a temporal-difference prediction error during cerebellar learning in mice

Nature neuroscience, 2015-12, Vol.18 (12), p.1798-1803 [Peer Reviewed Journal]

COPYRIGHT 2015 Nature Publishing Group ;COPYRIGHT 2015 Nature Publishing Group ;Copyright Nature Publishing Group Dec 2015 ;ISSN: 1097-6256 ;EISSN: 1546-1726 ;DOI: 10.1038/nn.4167 ;PMID: 26551541 ;CODEN: NANEFN

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  • Title:
    Climbing fibers encode a temporal-difference prediction error during cerebellar learning in mice
  • Author: Ohmae, Shogo ; Medina, Javier F
  • Subjects: Action Potentials - physiology ; Animals ; Axons ; Cerebellum - cytology ; Cerebellum - physiology ; Forecasting ; Learning ; Learning - physiology ; Male ; Mice ; Mice, Inbred C57BL ; Neural transmission ; Observations ; Properties ; Psychological aspects ; Purkinje Cells - physiology ; Time Factors
  • Is Part Of: Nature neuroscience, 2015-12, Vol.18 (12), p.1798-1803
  • Description: Climbing fiber inputs to Purkinje cells are thought to be involved in generating the instructive signals that drive cerebellar learning. To investigate how these instructive signals are encoded, we recorded the activity of individual climbing fibers during cerebellum-dependent eyeblink conditioning in mice. We found that climbing fibers signaled both the unexpected delivery and the unexpected omission of the periocular airpuff that served as the instructive signal for eyeblink conditioning. In addition, we observed that climbing fibers activated by periocular airpuffs also responded to stimuli from other sensory modalities if those stimuli were novel or if they predicted that the periocular airpuff was about to be presented. This pattern of climbing fiber activity is markedly similar to the responses of dopamine neurons during reinforcement learning, which have been shown to encode a particular type of instructive signal known as a temporal difference prediction error.
  • Publisher: United States: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 1097-6256
    EISSN: 1546-1726
    DOI: 10.1038/nn.4167
    PMID: 26551541
    CODEN: NANEFN
  • Source: ProQuest One Psychology
    MEDLINE
    ProQuest Central
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