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Quality of Life Scores: An Independent Prognostic Variable in a General Population of Cancer Patients Receiving Chemotherapy

Quality of life research, 1997-03, Vol.6 (2), p.151-158 [Peer Reviewed Journal]

Copyright 1997 Rapid Science Publishers ;Chapman and Hall 1997 ;ISSN: 0962-9343 ;EISSN: 1573-2649 ;DOI: 10.1023/A:1026442201191

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  • Title:
    Quality of Life Scores: An Independent Prognostic Variable in a General Population of Cancer Patients Receiving Chemotherapy
  • Author: J. Dancey ; B. Zee ; D. Osoba ; M. Whitehead ; F. Lu ; L. Kaizer ; Latreille, J. ; J. L. Pater
  • Subjects: Biological and medical sciences ; Breast cancer ; Cancer ; Chemotherapy ; Clinical trials ; Experimentation ; Lung diseases ; Lung neoplasms ; Medical sciences ; Metastasis ; Miscellaneous ; Neoplasia ; Ovarian cancer ; Ovarian diseases ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Quality of life
  • Is Part Of: Quality of life research, 1997-03, Vol.6 (2), p.151-158
  • Description: This report examines the prognostic associations between QOL scores measured by the EORTC QLQ-C30 and survival in a large heterogeneous population of cancer patients. Eight hundred and fifty-one cancer patients who were to receive chemotherapy were enrolled in two National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) antiemetic trials. All patients completed the EORTC QLQ-C30 immediately prior to their first chemotherapy. Survival data were available and obtained for 474 of 639 patients (74%). Cox's proportional hazards model was used to assess the independent impact of QOL and demographic variables on survival. Presence of metastatic disease, diagnosis of lung or ovarian cancer, ECOG performance status, global quality of life and emotional functioning were significantly associated with survival. Global QOL was predictive in all patients, in subgroups of patients with metastatic disease, with breast and lung cancer and other tumour types. In patients with low global quality of life scores, patients with low emotional functioning ratings lived longer than did patients with high emotional functioning ratings. Patients with high global QOL live significantly longer than do patients with low global QOL. The relationship between emotional functioning in patients with low global QOL and survival needs confirmation.
  • Publisher: Dordrecht: Rapid Communications of Oxford Ltd
  • Language: English
  • Identifier: ISSN: 0962-9343
    EISSN: 1573-2649
    DOI: 10.1023/A:1026442201191
  • Source: ProQuest One Psychology
    Alma/SFX Local Collection
    ProQuest Central
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