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Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging : Histopathological and displacement encoding with stimulated echoes (DENSE) functional validations

Circulation (New York, N.Y.), 2006-04, Vol.113 (15), p.1865-1870 [Peer Reviewed Journal]

2006 INIST-CNRS ;ISSN: 0009-7322 ;EISSN: 1524-4539 ;DOI: 10.1161/CIRCULATIONAHA.105.576025 ;PMID: 16606793 ;CODEN: CIRCAZ

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Title:
Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging : Histopathological and displacement encoding with stimulated echoes (DENSE) functional validations
Author: ALETRAS, Anthony H ; TILAK, Gauri S ; NATANZON, Alex ; HSU, Li-Yueh ; GONZALEZ, Felix M ; HOYT, Robert F ; ARAI, Andrew E
Subjects: Animals ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood. Blood coagulation. Reticuloendothelial system ; Cardiology. Vascular system ; Coronary heart disease ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Dogs ; Echocardiography - methods ; Edema, Cardiac - diagnosis ; Heart ; Heart - physiopathology ; Magnetic Resonance Imaging ; Medical sciences ; Microspheres ; Myocardial Infarction - diagnosis ; Myocardial Infarction - physiopathology ; Myocardial Infarction - therapy ; Myocardial Reperfusion ; Myocardium - pathology ; Pharmacology. Drug treatments ; Recovery of Function ; Reproducibility of Results ; Risk Factors ; Time Factors
Is Part Of: Circulation (New York, N.Y.), 2006-04, Vol.113 (15), p.1865-1870
Description: The aim of this study was to determine whether edema imaging by T2-weighted cardiac magnetic resonance (CMR) imaging could retrospectively delineate the area at risk in reperfused myocardial infarction. We hypothesized that the size of the area at risk during a transient occlusion would be similar to the T2-weighted hyperintense region observed 2 days later, that the T2-weighted hyperintense myocardium would show partial functional recovery after 2 months, and that the T2 abnormality would resolve over 2 months. Seventeen dogs underwent a 90-minute coronary artery occlusion, followed by reperfusion. The area at risk, as measured with microspheres (9 animals), was comparable to the size of the hyperintense zone on T2-weighted images 2 days later (43.4+/-3.3% versus 43.0+/-3.4% of the left ventricle; P=NS), and the 2 measures correlated (R=0.84). The infarcted zone was significantly smaller (23.1+/-3.7; both P<0.001). To test whether the hyperintense myocardium would exhibit partial functional recovery over time, 8 animals were imaged on day 2 and 2 months later. Systolic strain was mapped with displacement encoding with stimulated echoes. Edema, as detected by a hyperintense zone on T2-weighted images, resolved, and regional radial systolic strain partially improved from 4.9+/-0.7 to 13.1+/-1.5 (P=0.001) over 2 months. These findings are consistent with the premise that the T2 abnormality depicts the area at risk, a zone of reversibly and irreversibly injured myocardium associated with reperfused subendocardial infarctions. The persistence of postischemic edema allows T2-weighted CMR to delineate the area at risk 2 days after reperfused myocardial infarction.
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
Language: English
Identifier: ISSN: 0009-7322
EISSN: 1524-4539
DOI: 10.1161/CIRCULATIONAHA.105.576025
PMID: 16606793
CODEN: CIRCAZ
Source: GFMER Free Medical Journals
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Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging : Histopathological and displacement encoding with stimulated echoes (DENSE) functional validations

2006 INIST-CNRS ;ISSN: 0009-7322 ;EISSN: 1524-4539 ;DOI: 10.1161/CIRCULATIONAHA.105.576025 ;PMID: 16606793 ;CODEN: CIRCAZ

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