Language:

Selection of resistant bacteria at very low antibiotic concentrations

PLoS pathogens, 2011-07, Vol.7 (7), p.e1002158 [Peer Reviewed Journal]

COPYRIGHT 2011 Public Library of Science ;COPYRIGHT 2011 Public Library of Science ;2011 Gullberg et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Gullberg E, Cao S, Berg OG, Ilbäck C, Sandegren L, et al. (2011) Selection of Resistant Bacteria at Very Low Antibiotic Concentrations. PLoS Pathog 7(7): e1002158. doi:10.1371/journal.ppat.1002158 ;Gullberg et al. 2011 ;ISSN: 1553-7374 ;ISSN: 1553-7366 ;EISSN: 1553-7374 ;DOI: 10.1371/journal.ppat.1002158 ;PMID: 21811410

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Selection of resistant bacteria at very low antibiotic concentrations
Author: Gullberg, Erik ; Cao, Sha ; Berg, Otto G ; Ilbäck, Carolina ; Sandegren, Linus ; Hughes, Diarmaid ; Andersson, Dan I
Lipsitch, Marc
Subjects: Anti-Bacterial Agents - pharmacology ; Antibiotics ; Bacteria ; Bacterial infections ; Base Sequence ; Biology ; Competition ; Dose-Response Relationship, Drug ; Drug resistance in microorganisms ; Drug Resistance, Bacterial - drug effects ; Drug Resistance, Bacterial - physiology ; E coli ; Escherichia coli - genetics ; Escherichia coli - growth & development ; Experiments ; Growth rate ; Health aspects ; Mathematical models ; Medical research ; MEDICIN ; MEDICINE ; Microbiology ; Models, Biological ; Molecular Sequence Data ; Salmonella typhimurium - genetics ; Salmonella typhimurium - growth & development ; Selection, Genetic - drug effects ; Selection, Genetic - physiology ; Veterinary medicine
Is Part Of: PLoS pathogens, 2011-07, Vol.7 (7), p.e1002158
Description: The widespread use of antibiotics is selecting for a variety of resistance mechanisms that seriously challenge our ability to treat bacterial infections. Resistant bacteria can be selected at the high concentrations of antibiotics used therapeutically, but what role the much lower antibiotic concentrations present in many environments plays in selection remains largely unclear. Here we show using highly sensitive competition experiments that selection of resistant bacteria occurs at extremely low antibiotic concentrations. Thus, for three clinically important antibiotics, drug concentrations up to several hundred-fold below the minimal inhibitory concentration of susceptible bacteria could enrich for resistant bacteria, even when present at a very low initial fraction. We also show that de novo mutants can be selected at sub-MIC concentrations of antibiotics, and we provide a mathematical model predicting how rapidly such mutants would take over in a susceptible population. These results add another dimension to the evolution of resistance and suggest that the low antibiotic concentrations found in many natural environments are important for enrichment and maintenance of resistance in bacterial populations.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1553-7374
ISSN: 1553-7366
EISSN: 1553-7374
DOI: 10.1371/journal.ppat.1002158
PMID: 21811410
Source: Public Library of Science (PLoS) Journals Open Access
GFMER Free Medical Journals
MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Selection of resistant bacteria at very low antibiotic concentrations

Searching Remote Databases, Please Wait