Language:

Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

Nature genetics, 2016-05, Vol.48 (5), p.552-555 [Peer Reviewed Journal]

COPYRIGHT 2016 Nature Publishing Group ;COPYRIGHT 2016 Nature Publishing Group ;Copyright Nature Publishing Group May 2016 ;ISSN: 1061-4036 ;EISSN: 1546-1718 ;DOI: 10.1038/ng.3529 ;PMID: 26998691

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population
Author: Robinson, Elise B ; St Pourcain, Beate ; Anttila, Verneri ; Kosmicki, Jack A ; Bulik-Sullivan, Brendan ; Grove, Jakob ; Maller, Julian ; Samocha, Kaitlin E ; Sanders, Stephan J ; Ripke, Stephan ; Martin, Joanna ; Hollegaard, Mads V ; Werge, Thomas ; Hougaard, David M ; Neale, Benjamin M ; Evans, David M ; Skuse, David ; Mortensen, Preben Bo ; Børglum, Anders D ; Ronald, Angelica ; Smith, George Davey ; Daly, Mark J
Subjects: Adult ; Autism ; Autism Spectrum Disorder - genetics ; Behavior ; Child ; Communication ; Communication Disorders - genetics ; Consortia ; Datasets ; Epidemiology ; Families & family life ; Female ; Genetic aspects ; Genetic Predisposition to Disease ; Genetic research ; Genetic susceptibility ; Genetic Variation ; Genetics, Population ; Genome-Wide Association Study ; Genomes ; Genotype ; Grants ; Health aspects ; Health Status Indicators ; Humans ; Influence ; Laboratories ; Liability ; Male ; Medical research ; Mental disorders ; Mental Disorders - genetics ; Mental health care ; Methods ; Pervasive developmental disorders ; Population ; Risk factors ; Studies
Is Part Of: Nature genetics, 2016-05, Vol.48 (5), p.552-555
Description: Almost all genetic risk factors for autism spectrum disorders (ASDs) can be found in the general population, but the effects of this risk are unclear in people not ascertained for neuropsychiatric symptoms. Using several large ASD consortium and population-based resources (total n > 38,000), we find genome-wide genetic links between ASDs and typical variation in social behavior and adaptive functioning. This finding is evidenced through both LD score correlation and de novo variant analysis, indicating that multiple types of genetic risk for ASDs influence a continuum of behavioral and developmental traits, the severe tail of which can result in diagnosis with an ASD or other neuropsychiatric disorder. A continuum model should inform the design and interpretation of studies of neuropsychiatric disease biology.
Publisher: United States: Nature Publishing Group
Language: English
Identifier: ISSN: 1061-4036
EISSN: 1546-1718
DOI: 10.1038/ng.3529
PMID: 26998691
Source: GFMER Free Medical Journals
MEDLINE
ProQuest Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

COPYRIGHT 2016 Nature Publishing Group ;COPYRIGHT 2016 Nature Publishing Group ;Copyright Nature Publishing Group May 2016 ;ISSN: 1061-4036 ;EISSN: 1546-1718 ;DOI: 10.1038/ng.3529 ;PMID: 26998691

Searching Remote Databases, Please Wait