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Human gut microbiome viewed across age and geography

Nature (London), 2012-06, Vol.486 (7402), p.222-227 [Peer Reviewed Journal]

2015 INIST-CNRS ;COPYRIGHT 2012 Nature Publishing Group ;COPYRIGHT 2012 Nature Publishing Group ;Copyright Nature Publishing Group Jun 14, 2012 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/nature11053 ;PMID: 22699611 ;CODEN: NATUAS

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Title:
Human gut microbiome viewed across age and geography
Author: YATSUNENKO, Tanya ; REY, Federico E ; HEATH, Andrew C ; WARNER, Barbara ; REEDER, Jens ; KUCZYNSKI, Justin ; GREGORY CAPORASO, J ; LOZUPONE, Catherine A ; LAUBER, Christian ; CARLOS CLEMENTE, Jose ; KNIGHTS, Dan ; KNIGHT, Rob ; MANARY, Mark J ; GORDON, Jeffrey I ; TREHAN, Indi ; DOMINGUEZ-BELLO, Maria Gloria ; CONTRERAS, Monica ; MAGRIS, Magda ; HIDALGO, Glida ; BALDASSANO, Robert N ; ANOKHIN, Andrey P
Subjects: Adolescent ; Adult ; Age Factors ; Aged ; Bacteria - classification ; Bacteria - genetics ; Bacteriology ; Biodiversity ; Biological and medical sciences ; Child ; Child, Preschool ; Families & family life ; Feces - microbiology ; Female ; Fundamental and applied biological sciences. Psychology ; Geography ; Humans ; Infant ; Intestines - microbiology ; Malawi ; Male ; Metagenome ; Microbiology ; Middle Aged ; Morphology, structure, chemical composition ; Nutrition research ; Phylogenetics ; Phylogeny ; RNA, Ribosomal, 16S - genetics ; Studies ; Traditions ; Twins ; Twins, Dizygotic ; Twins, Monozygotic ; United States ; Venezuela ; Young Adult
Is Part Of: Nature (London), 2012-06, Vol.486 (7402), p.222-227
Description: Gut microbial communities represent one source of human genetic and metabolic diversity. To examine how gut microbiomes differ among human populations, here we characterize bacterial species in fecal samples from 531 individuals, plus the gene content of 110 of them. The cohort encompassed healthy children and adults from the Amazonas of Venezuela, rural Malawi and US metropolitan areas and included mono- and dizygotic twins. Shared features of the functional maturation of the gut microbiome were identified during the first three years of life in all three populations, including age-associated changes in the genes involved in vitamin biosynthesis and metabolism. Pronounced differences in bacterial assemblages and functional gene repertoires were noted between US residents and those in the other two countries. These distinctive features are evident in early infancy as well as adulthood. Our findings underscore the need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization.
Publisher: London: Nature Publishing Group
Language: English
Identifier: ISSN: 0028-0836
EISSN: 1476-4687
DOI: 10.1038/nature11053
PMID: 22699611
CODEN: NATUAS
Source: ProQuest One Psychology
AUTh Library subscriptions: ProQuest Central
MEDLINE
Alma/SFX Local Collection

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Human gut microbiome viewed across age and geography

2015 INIST-CNRS ;COPYRIGHT 2012 Nature Publishing Group ;COPYRIGHT 2012 Nature Publishing Group ;Copyright Nature Publishing Group Jun 14, 2012 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/nature11053 ;PMID: 22699611 ;CODEN: NATUAS

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