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Management of endometrial, ovarian and cervical cancer in the elderly: current approach to a challenging condition

Archives of gynecology and obstetrics, 2019-02, Vol.299 (2), p.299-315 [Peer Reviewed Journal]

Springer-Verlag GmbH Germany, part of Springer Nature 2018 ;Archives of Gynecology and Obstetrics is a copyright of Springer, (2018). All Rights Reserved. ;ISSN: 0932-0067 ;EISSN: 1432-0711 ;DOI: 10.1007/s00404-018-5006-z ;PMID: 30542793

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Title:
Management of endometrial, ovarian and cervical cancer in the elderly: current approach to a challenging condition
Author: Vitale, Salvatore Giovanni ; Capriglione, Stella ; Zito, Gabriella ; Lopez, Salvatore ; Gulino, Ferdinando Antonio ; Di Guardo, Federica ; Vitagliano, Amerigo ; Noventa, Marco ; La Rosa, Valentina Lucia ; Sapia, Fabrizio ; Valenti, Gaetano ; Rapisarda, Agnese Maria Chiara ; Peterlunger, Isabel ; Rossetti, Diego ; Laganà, Antonio Simone
Subjects: Aged ; Aged, 80 and over ; Cervical cancer ; Endocrinology ; Endometrial cancer ; Endometrial Neoplasms - therapy ; Female ; Genital Neoplasms, Female - therapy ; Gynecology ; Human Genetics ; Humans ; Medicine ; Medicine & Public Health ; Obstetrics/Perinatology/Midwifery ; Older people ; Ovarian cancer ; Ovarian Neoplasms - therapy ; Review ; Uterine Cervical Neoplasms - therapy
Is Part Of: Archives of gynecology and obstetrics, 2019-02, Vol.299 (2), p.299-315
Description: Purpose Gynaecological cancer management in older people represents a current challenge. Therefore, in the present paper, we aimed to gather all the evidence reported in the literature concerning gynecological cancers in the elderly, illustrating the state of art and the future perspectives. Methods We searched MEDLINE (PubMed), EMBASE, Cochrane Central Register of Controlled Trials, IBECS, BIOSIS, Web of Science, SCOPUS and Grey literature (Google Scholar; British Library) from January 1952 to May 2017, using the terms “ovarian cancer”, “endometrial cancer”, “cervical cancer”, “gynecological cancers” combined with ‘elderly’, ‘cancer’, ‘clinical trial’ and ‘geriatric assessment’. Results The search identified 81 citations, of which 65 were potentially relevant after initial evaluation and met the criteria for inclusion and were analyzed. We divided all included studies into three different issue: “Endometrial cancer”, “Ovarian cancer” and “Cervical cancer”. Conclusions The present literature review shows that, in spite of the higher burden of comorbidities, elderly patients can also benefit from standard treatment to manage their gynecological cancers. It is important to overcome the common habit of undertreating the elderly patients because they are more fragile and with a lower life expectancy than their younger counterpart. Further trials with elderly women are warranted.
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
Language: English
Identifier: ISSN: 0932-0067
EISSN: 1432-0711
DOI: 10.1007/s00404-018-5006-z
PMID: 30542793
Source: MEDLINE
ProQuest Central

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Management of endometrial, ovarian and cervical cancer in the elderly: current approach to a challenging condition

Springer-Verlag GmbH Germany, part of Springer Nature 2018 ;Archives of Gynecology and Obstetrics is a copyright of Springer, (2018). All Rights Reserved. ;ISSN: 0932-0067 ;EISSN: 1432-0711 ;DOI: 10.1007/s00404-018-5006-z ;PMID: 30542793

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