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Clinical analysis of 22 cases of cutaneous adverse reactions caused by molecular targeted antitumor agents and immune checkpoint inhibitors

Pifu-xingbing zhenliaoxue zazhi, 2023-12, Vol.30 (6), p.539-543

ISSN: 1674-8468 ;DOI: 10.3969/j.issn.1674-8468.2023.06.010

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  • Title:
    Clinical analysis of 22 cases of cutaneous adverse reactions caused by molecular targeted antitumor agents and immune checkpoint inhibitors
  • Author: Kui MU ; Xingyu ZHOU ; Yaping LI
  • Subjects: dermal adverse reaction ; immune checkpoint inhibitors ; targeted drug
  • Is Part Of: Pifu-xingbing zhenliaoxue zazhi, 2023-12, Vol.30 (6), p.539-543
  • Description: Objective To analyze cutaneous adverse reactions induced by immune checkpoint inhibitors and targeted antitumor drugs. Methods We retrospectively analyzed the clinical data of 22 cases of cutaneous adverse reactions caused by molecular targeted antitumor agents and immune checkpoint inhibitors. Results The time between the occurrence of skin adverse reactions and the first use of targeted drugs or ICIs ranged from 1 day to 4 years, with an average of 7 months. Inpatients with CTCAE grades 3 and 4 accounted for 90.91% and 9.09%, respectively. Majority of CTCAE-grade 3 patients (90.00%) mainly presented with erythema and papules, and 15.00% of patients had mucous involvement. Two CTCAE-grade 4 patients were diagnosed with drug-induced bullosa epidermolysis, accompanied by elevated inflammatory markers and abnormal liver function. The pathological findings of 8 patients with bullous pemphigoid, psoriasis or perforating collagen disease were similar to those of idiopathic diseases. All patients were discharged fr
  • Publisher: editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
  • Language: Chinese
  • Identifier: ISSN: 1674-8468
    DOI: 10.3969/j.issn.1674-8468.2023.06.010
  • Source: DOAJ Directory of Open Access Journals
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