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Adrenocortical 11β-Hydroxylase Deficiency and Virilism First Manifest in the Adult Woman

The New England journal of medicine, 1965-06, Vol.272 (23), p.1189-1194 [Peer Reviewed Journal]

ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJM196506102722301

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  • Title:
    Adrenocortical 11β-Hydroxylase Deficiency and Virilism First Manifest in the Adult Woman
  • Author: Gabrilove, J. L ; Sharma, D. C ; Dorfman, R. I
  • Subjects: Old Medline
  • Is Part Of: The New England journal of medicine, 1965-06, Vol.272 (23), p.1189-1194
  • Description: THIS report is concerned with the delineation and biochemical demonstration of a clinical syndrome first manifest in the adult woman and resulting from an 11β-hydroxylase deficiency in the adrenal cortex. Experimental Procedure Determination of Urinary Steroids The urinary excretion of the neutral 17-ketosteroids has been measured by a modification of the method of Drekter and Heisler 1 and of the 17-hydroxycorticoids by the Peterson modification 2 of the method of Silber and Porter. 3 The partition of the glucocorticoids and of the neutral 17-ketosteroids was carried out by methods previously described. 4 , 5 Pregnanetriol was assayed by the method of Bongiovanni and Eberlein. 6 For the . . .
  • Publisher: Massachusetts Medical Society
  • Language: English
  • Identifier: ISSN: 0028-4793
    EISSN: 1533-4406
    DOI: 10.1056/NEJM196506102722301
  • Source: Alma/SFX Local Collection
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