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Retrospective Birth Dating of Cells in Humans

Cell, 2005-07, Vol.122 (1), p.133-143 [Peer Reviewed Journal]

2005 Elsevier Inc. ;ISSN: 0092-8674 ;EISSN: 1097-4172 ;DOI: 10.1016/j.cell.2005.04.028 ;PMID: 16009139

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Title:
Retrospective Birth Dating of Cells in Humans
Author: Spalding, Kirsty L. ; Bhardwaj, Ratan D. ; Buchholz, Bruce A. ; Druid, Henrik ; Frisén, Jonas
Subjects: Adult ; Aging - physiology ; Air Pollutants, Radioactive - analysis ; Air Pollutants, Radioactive - metabolism ; Carbon Radioisotopes - analysis ; Carbon Radioisotopes - pharmacokinetics ; Cell Nucleus - chemistry ; Cell Nucleus - metabolism ; Cellular Senescence - physiology ; Cerebral Cortex - cytology ; Cerebral Cortex - growth & development ; Cerebral Cortex - physiology ; DNA - biosynthesis ; DNA - chemistry ; Humans ; Male ; Medicin och hälsovetenskap ; Neurons - chemistry ; Neurons - cytology ; Neurons - physiology ; Nuclear Warfare - statistics & numerical data ; Organ Specificity ; Pinus - chemistry ; Retrospective Studies ; Time
Is Part Of: Cell, 2005-07, Vol.122 (1), p.133-143
Description: The generation of cells in the human body has been difficult to study, and our understanding of cell turnover is limited. Testing of nuclear weapons resulted in a dramatic global increase in the levels of the isotope 14C in the atmosphere, followed by an exponential decrease after 1963. We show that the level of 14C in genomic DNA closely parallels atmospheric levels and can be used to establish the time point when the DNA was synthesized and cells were born. We use this strategy to determine the age of cells in the cortex of the adult human brain and show that whereas nonneuronal cells are exchanged, occipital neurons are as old as the individual, supporting the view that postnatal neurogenesis does not take place in this region. Retrospective birth dating is a generally applicable strategy that can be used to measure cell turnover in man under physiological and pathological conditions.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0092-8674
EISSN: 1097-4172
DOI: 10.1016/j.cell.2005.04.028
PMID: 16009139
Source: MEDLINE
SWEPUB Freely available online
Open Access: Cell Press Free Archives

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Retrospective Birth Dating of Cells in Humans

2005 Elsevier Inc. ;ISSN: 0092-8674 ;EISSN: 1097-4172 ;DOI: 10.1016/j.cell.2005.04.028 ;PMID: 16009139

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