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Mitochondria-targeted drugs for diabetic kidney disease

Heliyon, 2022-02, Vol.8 (2), p.e08878-e08878, Article e08878 [Peer Reviewed Journal]

2022 The Author(s) ;2022 The Author(s). ;2022 The Author(s) 2022 ;ISSN: 2405-8440 ;EISSN: 2405-8440 ;DOI: 10.1016/j.heliyon.2022.e08878 ;PMID: 35265754

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  • Title:
    Mitochondria-targeted drugs for diabetic kidney disease
  • Author: Mima, Akira
  • Subjects: Diabetic kidney disease (DKD) ; Imeglimin ; Metformin ; Mitochondrial function ; NFE-2 related factor 2 (Nrf2) ; Reactive oxygen species (ROS) ; Review ; Sodium-glucose cotransporter 2 (SGLT2)
  • Is Part Of: Heliyon, 2022-02, Vol.8 (2), p.e08878-e08878, Article e08878
  • Description: Diabetic kidney disease (DKD) is one of the most frequent causes of chronic kidney disease (CKD) in the United States. Chronic hyperglycemic conditions are thought to be the primary cause of DKD. However, it is clinically difficult to achieve glycemic control in individuals with diabetes. Recent advances in mitochondrial biology have provided a new understanding of mitochondrial dysfunction in DKD. Studies have revealed impaired mitochondrial function in a variety of diabetic complications, including DKD; moreover, abnormal mitochondrial fission may be involved in the progression of DKD. It has been reported that metformin or sodium-glucose cotransporter 2 (SGLT2) inhibitors may provide renal protection by improving mitochondrial dynamics and reducing oxidative stress. Thus, drugs that target the restoration of mitochondrial function may become novel therapeutic agents for DKD. Imeglimin is the first in a new class of oral antidiabetic drugs that can reduce reactive oxygen species production and increase mitochondrial DNA synthesis. This review outlines the potential therapeutic interventions that affect mitochondrial function and prevent DKD. Diabetic kidney disease (DKD), Imeglimin, Metformin, Mitochondrial function, NFE-2 related factor 2 (Nrf2), Reactive oxygen species (ROS), Sodium-glucose cotransporter 2 (SGLT2).
  • Publisher: England: Elsevier Ltd
  • Language: English
  • Identifier: ISSN: 2405-8440
    EISSN: 2405-8440
    DOI: 10.1016/j.heliyon.2022.e08878
    PMID: 35265754
  • Source: PubMed Central
    ROAD: Directory of Open Access Scholarly Resources
    DOAJ Directory of Open Access Journals
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