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The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice

Science advances, 2019-02, Vol.5 (2), p.eaau8317-eaau8317 [Peer Reviewed Journal]

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). 2019 The Authors ;ISSN: 2375-2548 ;EISSN: 2375-2548 ;DOI: 10.1126/sciadv.aau8317 ;PMID: 30775438

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  • Title:
    The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice
  • Author: Zheng, Peng ; Zeng, Benhua ; Liu, Meiling ; Chen, Jianjun ; Pan, Junxi ; Han, Yu ; Liu, Yiyun ; Cheng, Ke ; Zhou, Chanjuan ; Wang, Haiyang ; Zhou, Xinyu ; Gui, Siwen ; Perry, Seth W ; Wong, Ma-Li ; Licinio, Julio ; Wei, Hong ; Xie, Peng
  • Subjects: Neuroscience ; SciAdv r-articles
  • Is Part Of: Science advances, 2019-02, Vol.5 (2), p.eaau8317-eaau8317
  • Description: Schizophrenia (SCZ) is a devastating mental disorder with poorly defined underlying molecular mechanisms. The gut microbiome can modulate brain function and behaviors through the microbiota-gut-brain axis. Here, we found that unmedicated and medicated patients with SCZ had a decreased microbiome α-diversity index and marked disturbances of gut microbial composition versus healthy controls (HCs). Several unique bacterial taxa (e.g., Veillonellaceae and Lachnospiraceae) were associated with SCZ severity. A specific microbial panel (Aerococcaceae, Bifidobacteriaceae, Brucellaceae, Pasteurellaceae, and Rikenellaceae) enabled discriminating patients with SCZ from HCs with 0.769 area under the curve. Compared to HCs, germ-free mice receiving SCZ microbiome fecal transplants had lower glutamate and higher glutamine and GABA in the hippocampus and displayed SCZ-relevant behaviors similar to other mouse models of SCZ involving glutamatergic hypofunction. Together, our findings suggest that the SCZ microbiome itself can alter neurochemistry and neurologic function in ways that may be relevant to SCZ pathology.
  • Publisher: United States: American Association for the Advancement of Science
  • Language: English
  • Identifier: ISSN: 2375-2548
    EISSN: 2375-2548
    DOI: 10.1126/sciadv.aau8317
    PMID: 30775438
  • Source: PubMed Central
    DOAJ: Directory of Open Access Journals
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