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Macrophages Keep Your Gut Moving

Molecules and Cells, 2023, 46(11), , pp.672-674 [Peer Reviewed Journal]

ISSN: 1016-8478 ;EISSN: 0219-1032 ;DOI: 10.14348/molcells.2023.0125 ;PMID: 37968981

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  • Title:
    Macrophages Keep Your Gut Moving
  • Author: Lee, Chan Hee ; Kim, Min-Seon
  • Subjects: Gastrointestinal Tract ; Macrophages ; 생물학
  • Is Part Of: Molecules and Cells, 2023, 46(11), , pp.672-674
  • Description: Schematic diagram of the interaction between the intestinal muscularis externa (MMΦ) macrophages and the enteric nervous system (ENS) neurons during different developmental periods. At the early postnatal stage, MMΦs play a critical role in ENS maturation and refinement through synaptic pruning and enteric neuron phagocytosis. In addition, during the adult stage, a specific MMΦ subset named neuron-associated (NA)-MMΦ, supports enteric neuronal survival and functions. Conversely, enteric neurons promote the phenotypic MMΦ changes by secreting transforming growth factor-β (TGFβ), transitioning them from a phagocytic phenotype in the early postnatal period to a neuroprotective and immune-surveillant phenotype in the young adult period. Disruptions in these interactions could lead to alterations in the enteric neuron numbers, ultimately resulting in reduced gut motility.
  • Publisher: United States: 한국분자세포생물학회
  • Language: English;Korean
  • Identifier: ISSN: 1016-8478
    EISSN: 0219-1032
    DOI: 10.14348/molcells.2023.0125
    PMID: 37968981
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    MEDLINE
    PubMed Central
    Alma/SFX Local Collection
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