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Diterpenoids from Rosmarinus officinalis L. and their nitric oxide inhibitory activity

Vietnam journal of chemistry, 2021-04, Vol.59 (2), p.229-234 [Peer Reviewed Journal]

2021 Vietnam Academy of Science and Technology, Hanoi & Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim ;ISSN: 0866-7144 ;EISSN: 2572-8288 ;DOI: 10.1002/vjch.202000161

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  • Title:
    Diterpenoids from Rosmarinus officinalis L. and their nitric oxide inhibitory activity
  • Author: Huyen, Le Thi ; Oanh, Le Thi
  • Subjects: abietane diterpenoid ; icetexane diterpenoid ; nitric oxide inhibitor ; Rosmarinus officinalis
  • Is Part Of: Vietnam journal of chemistry, 2021-04, Vol.59 (2), p.229-234
  • Description: One icetexane diterpenoid, demethylsalvicanol (1) and four abietane diterpenoids, sageone (2), 20‐deoxocarnosol (3), 11,12,20‐trihydroxy‐abieta‐8,11,13‐triene (4), and 7αα‐ethoxyrosmanol (5) were isolated from the n‐hexane layer of the leaves and twigs of Rosmarinus officinalis L. Chemical structures of compounds were identified by ESI‐MS, 1D‐, 2D‐NMR spectra and by comparison of the spectral data in the literature. Compounds 1‐5 were evaluated anti‐inflammatory activity by inhibitory NO production, LPS stimulated on RAW 264.7 cells. At a concentration of 100 μM, compound 4 exhibited inhibitory percentage of 34.7±1.8 %, meanwhile compounds 1‐3 and 5 showed cytotoxic effect. After dilution to concentration of 20 μM, except compound 1 and 2, compounds 3‐5 did not show cytotoxic effect. Their NO inhibitory productions were ranging from 20.5±2.4 % to 26.7±1.9 %. Compounds 1, 3 and 4 have been reported for the first time from the Rosmarinus genus.
  • Publisher: Weinheim: WILEY‐VCH Verlag GmbH & Co. KGaA
  • Language: English
  • Identifier: ISSN: 0866-7144
    EISSN: 2572-8288
    DOI: 10.1002/vjch.202000161
  • Source: Alma/SFX Local Collection
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