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Disrupted global metastability and static and dynamic brain connectivity across individuals in the Alzheimer's disease continuum

Scientific reports, 2017-01, Vol.7 (1), p.40268-40268, Article 40268 [Peer Reviewed Journal]

Copyright Nature Publishing Group Jan 2017 ;info:eu-repo/semantics/openAccess ;Copyright © 2017, The Author(s) 2017 The Author(s) ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep40268 ;PMID: 28074926

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Title:
Disrupted global metastability and static and dynamic brain connectivity across individuals in the Alzheimer's disease continuum
Author: Córdova-Palomera, Aldo ; Kaufmann, Tobias ; Persson, Karin ; Alnæs, Dag ; Doan, Nhat Trung ; Moberget, Torgeir ; Lund, Martina Jonette ; Barca, Maria Lage ; Engvig, Andreas ; Brækhus, Anne ; Engedal, Knut ; Andreassen, Ole A ; Selbæk, Geir ; Westlye, Lars T
Subjects: Aged ; Alzheimer Disease - physiopathology ; Alzheimer's disease ; Alzheimers disease ; Brain ; Brain - physiopathology ; Brain Mapping ; Cognitive ability ; Cognitive Dysfunction - physiopathology ; Cross-Sectional Studies ; Female ; Functional magnetic resonance imaging ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Nervous system ; Neural networks ; Neural Pathways - physiopathology ; Neurodegenerative diseases ; Nodes ; Putamen
Is Part Of: Scientific reports, 2017-01, Vol.7 (1), p.40268-40268, Article 40268
Description: As findings on the neuropathological and behavioral components of Alzheimer's disease (AD) continue to accrue, converging evidence suggests that macroscale brain functional disruptions may mediate their association. Recent developments on theoretical neuroscience indicate that instantaneous patterns of brain connectivity and metastability may be a key mechanism in neural communication underlying cognitive performance. However, the potential significance of these patterns across the AD spectrum remains virtually unexplored. We assessed the clinical sensitivity of static and dynamic functional brain disruptions across the AD spectrum using resting-state fMRI in a sample consisting of AD patients (n = 80) and subjects with either mild (n = 44) or subjective (n = 26) cognitive impairment (MCI, SCI). Spatial maps constituting the nodes in the functional brain network and their associated time-series were estimated using spatial group independent component analysis and dual regression, and whole-brain oscillatory activity was analyzed both globally (metastability) and locally (static and dynamic connectivity). Instantaneous phase metrics showed functional coupling alterations in AD compared to MCI and SCI, both static (putamen, dorsal and default-mode) and dynamic (temporal, frontal-superior and default-mode), along with decreased global metastability. The results suggest that brains of AD patients display altered oscillatory patterns, in agreement with theoretical premises on cognitive dynamics.
Publisher: England: Nature Publishing Group
Language: English;Norwegian
Identifier: ISSN: 2045-2322
EISSN: 2045-2322
DOI: 10.1038/srep40268
PMID: 28074926
Source: MEDLINE
NORA Norwegian Open Research Archives
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Disrupted global metastability and static and dynamic brain connectivity across individuals in the Alzheimer's disease continuum

Copyright Nature Publishing Group Jan 2017 ;info:eu-repo/semantics/openAccess ;Copyright © 2017, The Author(s) 2017 The Author(s) ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep40268 ;PMID: 28074926

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