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Risk factors associated with the mortality rate of oral squamous cell carcinoma patients: A 10-year retrospective study

Medicine (Baltimore), 2021-09, Vol.100 (36), p.e27127-e27127 [Peer Reviewed Journal]

Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. ;Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. 2021 ;ISSN: 0025-7974 ;EISSN: 1536-5964 ;DOI: 10.1097/MD.0000000000027127 ;PMID: 34516504

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  • Title:
    Risk factors associated with the mortality rate of oral squamous cell carcinoma patients: A 10-year retrospective study
  • Author: Ahmad, Paras ; Nawaz, Rubbia ; Qurban, Maria ; Shaikh, Gul Muhammad ; Mohamed, Roshan Noor ; Nagarajappa, Anil Kumar ; Asif, Jawaad Ahmed ; Alam, Mohammad Khursheed
  • Subjects: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell - etiology ; Carcinoma, Squamous Cell - mortality ; Cross-Sectional Studies ; Female ; Humans ; Malaysia ; Male ; Middle Aged ; Mouth Neoplasms - etiology ; Mouth Neoplasms - mortality ; Observational Study ; Retrospective Studies ; Risk Factors ; Survival Analysis ; Young Adult
  • Is Part Of: Medicine (Baltimore), 2021-09, Vol.100 (36), p.e27127-e27127
  • Description: In Malaysia, oral cancer is very common and the reported 5-year survival of such patients is nearly 50% after treatment with surgery and radiotherapy, much lower than most of the developed countries. This study aimed to investigate the socio-demographic and clinicopathological parameters that influence the mortality rate of the patients suffering from oral squamous cell carcinoma (OSCC) in the Kelantanse population.In this retrospective study, data regarding socio-demographic, clinicopathological factors, and treatment outcome associated with OSCC were gathered from the archives of the medical records office of Hospital Universiti Sains Malaysia. For statistical analysis, simple and multiple logistic regression were performed. The significance level was set to P < .25.A total of 211 OSCC cases were registered in Hospital Universiti Sains Malaysia from January 1, 2000 to December 31, 2018. Majority of them were male (57.82%), non-smoker (54.97%), non-alcohol consumer (91.94%), and non-betel quid chewer (93.83%) Malay (60.66%) patients. The tongue was the most commonly involved part of the oral cavity (41.52%). Histologically, the majority of the cases had moderately-differentiated OSCC (52.82%). Most of the patients were diagnosed at stage IV at the time of diagnosis (61.61%). When this study was performed, the survival status of the majority of the patients was alive (68.24%).Within the analyzed socio-demographic and clinicopathological parameters, gender, alcohol consumption, T-classification, histological grading, and treatment status have been demonstrated as an independent risk factors for mortality rate in multivariate analysis. Hence, these parameters need to be taken into account for the individualized therapy management of OSCC patients.
  • Publisher: United States: Lippincott Williams & Wilkins
  • Language: English
  • Identifier: ISSN: 0025-7974
    EISSN: 1536-5964
    DOI: 10.1097/MD.0000000000027127
    PMID: 34516504
  • Source: IngentaConnect Free/Open Access Journals
    Journals@Ovid Open Access Journal Collection Rolling
    Wolters Kluwer Open Health
    MEDLINE
    PubMed Central
    DOAJ Directory of Open Access Journals
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