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Vitamin D intake, blood 25(OH)D levels, and breast cancer risk or mortality: a meta-analysis

British journal of cancer, 2014-05, Vol.110 (11), p.2772-2784 [Peer Reviewed Journal]

2015 INIST-CNRS ;Copyright Nature Publishing Group May 27, 2014 ;Copyright © 2014 Cancer Research UK 2014 Cancer Research UK ;ISSN: 0007-0920 ;EISSN: 1532-1827 ;DOI: 10.1038/bjc.2014.175 ;PMID: 24714744 ;CODEN: BJCAAI

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  • Title:
    Vitamin D intake, blood 25(OH)D levels, and breast cancer risk or mortality: a meta-analysis
  • Author: KIM, Y ; JE, Y
  • Subjects: Biological and medical sciences ; Breast Neoplasms - blood ; Breast Neoplasms - mortality ; Breast Neoplasms - prevention & control ; Diet ; Epidemiology ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Mammary gland diseases ; Medical sciences ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Prospective Studies ; Risk ; Tumors ; Vitamin D - analogs & derivatives ; Vitamin D - blood
  • Is Part Of: British journal of cancer, 2014-05, Vol.110 (11), p.2772-2784
  • Description: Experimental studies suggest potential anti-carcinogenic properties of vitamin D against breast cancer risk, but the epidemiological evidence to date is inconsistent. We searched MEDLINE and EMBASE databases along with a hand search for eligible studies to examine the association between vitamin D status (based on diet and blood 25-hydroxyvitamin D (25(OH)D)) and breast cancer risk or mortality in a meta-analysis. A random-effect model was used to calculate a pooled adjusted relative risk (RR). A total of 30 prospective studies (nested case-control or cohort) were included for breast cancer incidence (n=24 studies; 31 867 cases) or mortality (n=6 studies; 870 deaths) among 6092 breast cancer patients. The pooled RRs of breast cancer incidence for the highest vs the lowest vitamin D intake and blood 25(OH)D levels were 0.95 (95% CI: 0.88-1.01) and 0.92 (95% CI: 0.83-1.02), respectively. Among breast cancer patients, high blood 25(OH)D levels were significantly associated with lower breast cancer mortality (pooled RR=0.58, 95% CI: 0.40-0.85) and overall mortality (pooled RR=0.61, 95% CI: 0.48-0.79). There was no evidence of heterogeneity and publication bias. Our findings suggest that high vitamin D status is weakly associated with low breast cancer risk but strongly associated with better breast cancer survival.
  • Publisher: Basingstoke: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 0007-0920
    EISSN: 1532-1827
    DOI: 10.1038/bjc.2014.175
    PMID: 24714744
    CODEN: BJCAAI
  • Source: PubMed Central (Open access)
    Geneva Foundation Free Medical Journals at publisher websites
    AUTh Library subscriptions: ProQuest Central
    MEDLINE
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