Language:

Effects of Hyperglycemia and Effects of Ketosis on Cerebral Perfusion, Cerebral Water Distribution, and Cerebral Metabolism

Diabetes (New York, N.Y.), 2012-07, Vol.61 (7), p.1831-1837 [Peer Reviewed Journal]

2015 INIST-CNRS ;COPYRIGHT 2012 American Diabetes Association ;COPYRIGHT 2012 American Diabetes Association ;Copyright American Diabetes Association Jul 2012 ;2012 by the American Diabetes Association. 2012 ;ISSN: 0012-1797 ;EISSN: 1939-327X ;DOI: 10.2337/db11-1286 ;PMID: 22498698 ;CODEN: DIAEAZ

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Effects of Hyperglycemia and Effects of Ketosis on Cerebral Perfusion, Cerebral Water Distribution, and Cerebral Metabolism
Author: GLASER, Nicole ; NGO, Catherine ; ANDERSON, Steven ; YUEN, Natalie ; TRIFU, Alexandra ; O'DONNELL, Martha
Subjects: Adenosine Triphosphate - analysis ; Adenosine Triphosphate - metabolism ; Animals ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - analysis ; Aspartic Acid - metabolism ; Biological and medical sciences ; Brain Edema - etiology ; Brain Edema - metabolism ; Brain Edema - physiopathology ; Cerebrum ; Cerebrum - blood supply ; Cerebrum - metabolism ; Cerebrum - physiopathology ; Complications ; Diabetes Mellitus, Experimental - complications ; Diabetes Mellitus, Experimental - metabolism ; Diabetes Mellitus, Experimental - physiopathology ; Diabetes. Impaired glucose tolerance ; Diabetic Ketoacidosis - complications ; Diabetic Ketoacidosis - metabolism ; Diabetic Ketoacidosis - physiopathology ; Diet, High-Fat - adverse effects ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Hyperglycemia ; Hyperglycemia - metabolism ; Hyperglycemia - physiopathology ; Lactic Acid - analysis ; Lactic Acid - metabolism ; Magnetic Resonance Spectroscopy ; Medical sciences ; Phosphates - analysis ; Phosphates - metabolism ; Phosphocreatine - analysis ; Phosphocreatine - metabolism ; Physiological aspects ; Rats ; Water - analysis ; Water - metabolism
Is Part Of: Diabetes (New York, N.Y.), 2012-07, Vol.61 (7), p.1831-1837
Description: Diabetic ketoacidosis (DKA) may cause brain injuries in children. The mechanisms responsible are difficult to elucidate because DKA involves multiple metabolic derangements. We aimed to determine the independent effects of hyperglycemia and ketosis on cerebral metabolism, blood flow, and water distribution. We used magnetic resonance spectroscopy to measure ratios of cerebral metabolites (ATP to inorganic phosphate [Pi], phosphocreatine [PCr] to Pi, N-acetyl aspartate [NAA] to creatine [Cr], and lactate to Cr) and diffusion-weighted imaging and perfusion-weighted imaging to assess cerebral water distribution (apparent diffusion coefficient [ADC] values) and cerebral blood flow (CBF) in three groups of juvenile rats (hyperglycemic, ketotic, and normal control). ATP-to-Pi ratio was reduced in both hyperglycemic and ketotic rats in comparison with controls. PCr-to-Pi ratio was reduced in the ketotic group, and there was a trend toward reduction in the hyperglycemic group. No significant differences were observed in NAA-to-Cr or lactate-to-Cr ratio. Cortical ADC was reduced in both groups (indicating brain cell swelling). Cortical CBF was also reduced in both groups. We conclude that both hyperglycemia and ketosis independently cause reductions in cerebral high-energy phosphates, CBF, and cortical ADC values. These effects may play a role in the pathophysiology of DKA-related brain injury.
Publisher: Alexandria, VA: American Diabetes Association
Language: English
Identifier: ISSN: 0012-1797
EISSN: 1939-327X
DOI: 10.2337/db11-1286
PMID: 22498698
CODEN: DIAEAZ
Source: AUTh Library subscriptions: ProQuest Central
MEDLINE
PubMed Central
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Effects of Hyperglycemia and Effects of Ketosis on Cerebral Perfusion, Cerebral Water Distribution, and Cerebral Metabolism

2015 INIST-CNRS ;COPYRIGHT 2012 American Diabetes Association ;COPYRIGHT 2012 American Diabetes Association ;Copyright American Diabetes Association Jul 2012 ;2012 by the American Diabetes Association. 2012 ;ISSN: 0012-1797 ;EISSN: 1939-327X ;DOI: 10.2337/db11-1286 ;PMID: 22498698 ;CODEN: DIAEAZ

Searching Remote Databases, Please Wait