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Molybdenum derived from nanomaterials incorporates into molybdenum enzymes and affects their activities in vivo

Nature nanotechnology, 2021-06, Vol.16 (6), p.708-716 [Peer Reviewed Journal]

The Author(s), under exclusive licence to Springer Nature Limited 2021. ;ISSN: 1748-3387 ;EISSN: 1748-3395 ;DOI: 10.1038/s41565-021-00856-w ;PMID: 33603238

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Title:
Molybdenum derived from nanomaterials incorporates into molybdenum enzymes and affects their activities in vivo
Author: Cao, Mingjing ; Cai, Rong ; Zhao, Lina ; Guo, Mengyu ; Wang, Liming ; Wang, Yucai ; Zhang, Lili ; Wang, Xiaofeng ; Yao, Haodong ; Xie, Chunyu ; Cong, Yalin ; Guan, Yong ; Tao, Xiayu ; Wang, Yaling ; Xu, Shaoxin ; Liu, Ying ; Zhao, Yuliang ; Chen, Chunying
Subjects: Administration, Intravenous ; Animals ; Apolipoprotein E ; Apolipoproteins E - genetics ; Bioavailability ; Biological Availability ; Biomaterials ; Biomedical materials ; Biotransformation ; Blood Proteins - metabolism ; Coronas ; Disulfides - analysis ; Disulfides - pharmacokinetics ; Enzymes ; Female ; Intravenous administration ; Liver ; Liver - drug effects ; Liver - enzymology ; Liver - metabolism ; Long-term effects ; Macrophages - drug effects ; Macrophages - metabolism ; Metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Molecular dynamics ; Molecular Dynamics Simulation ; Molybdenum ; Molybdenum - analysis ; Molybdenum - blood ; Molybdenum - chemistry ; Molybdenum - pharmacokinetics ; Molybdenum disulfide ; Nanomaterials ; Nanostructures - administration & dosage ; Nanostructures - chemistry ; Nanotechnology ; Protein Corona - chemistry ; Protein Corona - metabolism ; Protein transport ; Proteins ; Red pulp ; Serum Albumin, Human - chemistry ; Serum Albumin, Human - metabolism ; Spleen ; Spleen - cytology ; Spleen - drug effects ; Tissue Distribution ; Trace elements
Is Part Of: Nature nanotechnology, 2021-06, Vol.16 (6), p.708-716
Description: Many nanoscale biomaterials fail to reach the clinical trial stage due to a poor understanding of the fundamental principles of their in vivo behaviour. Here we describe the transport, transformation and bioavailability of MoS nanomaterials through a combination of in vivo experiments and molecular dynamics simulations. We show that after intravenous injection molybdenum is significantly enriched in liver sinusoid and splenic red pulp. This biodistribution is mediated by protein coronas that spontaneously form in the blood, principally with apolipoprotein E. The biotransformation of MoS leads to incorporation of molybdenum into molybdenum enzymes, which increases their specific activities in the liver, affecting its metabolism. Our findings reveal that nanomaterials undergo a protein corona-bridged transport-transformation-bioavailability chain in vivo, and suggest that nanomaterials consisting of essential trace elements may be converted into active biological molecules that organisms can exploit. Our results also indicate that the long-term biotransformation of nanomaterials may have an impact on liver metabolism.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1748-3387
EISSN: 1748-3395
DOI: 10.1038/s41565-021-00856-w
PMID: 33603238
Source: MEDLINE
ProQuest Central

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Molybdenum derived from nanomaterials incorporates into molybdenum enzymes and affects their activities in vivo

The Author(s), under exclusive licence to Springer Nature Limited 2021. ;ISSN: 1748-3387 ;EISSN: 1748-3395 ;DOI: 10.1038/s41565-021-00856-w ;PMID: 33603238

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