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1,4-Dihydropyridines (DHPs) - a class of very potent drugs: syntheses of isotopically labeled DHP derivatives during the last four decades

Journal of labelled compounds & radiopharmaceuticals, 2007-08, Vol.50 (9-10), p.818-830 [Peer Reviewed Journal]

Copyright © 2007 John Wiley & Sons, Ltd. ;2008 INIST-CNRS ;ISSN: 0362-4803 ;EISSN: 1099-1344 ;DOI: 10.1002/jlcr.1418

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  • Title:
    1,4-Dihydropyridines (DHPs) - a class of very potent drugs: syntheses of isotopically labeled DHP derivatives during the last four decades
  • Author: Pleiss, U.
  • Subjects: Biological and medical sciences ; calcium antagonist ; carbon-11 ; carbon-13 ; carbon-14 ; Cardiovascular system ; Contrast media. Radiopharmaceuticals ; deuterium ; dihydropyridine ; iodine-125 ; Medical sciences ; Miscellaneous ; Pharmacology. Drug treatments ; tritium
  • Is Part Of: Journal of labelled compounds & radiopharmaceuticals, 2007-08, Vol.50 (9-10), p.818-830
  • Description: 1,4‐Dihydropyridines (DHPs) belonging to the group of calcium antagonists or calcium channel blockers' are among the most important drugs used in the treatment of cardiovascular diseases. During the development processes all candidates on the market have to be labeled with isotopes. Since the discovery of 1,4‐dihydropyridines (DHP) as cardiovascular drugs, the published syntheses for the labeling with radioactive isotopes like tritium, carbon‐11, carbon‐14, iodine‐125 and stable isotopes like deuterium and carbon‐13 are reviewed in the present report. The different synthetic routes are depicted and the synthesis details will be discussed with respect to the yields referred to labeled starting materials, specific activities and labeling degrees. Copyright © 2007 John Wiley & Sons, Ltd. 1,4‐Dihydropyridines (DHPs) belonging to the group of calcium antagonists or calcium channel blockers are among the most important drugs used in the treatment of cardiovascular diseases. The published labeling syntheses during the last 40 years with radioactive isotopes like 3H, 11C, 14C, 125I and stable isotopes like 2H and 13C will be reviewed. Copyright © 2007 John Wiley & Sons, Ltd.
  • Publisher: Chichester, UK: John Wiley & Sons, Ltd
  • Language: English
  • Identifier: ISSN: 0362-4803
    EISSN: 1099-1344
    DOI: 10.1002/jlcr.1418
  • Source: Alma/SFX Local Collection
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