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Effects of Intensive Glucose Lowering in Type 2 Diabetes

The New England journal of medicine, 2008-06, Vol.358 (24), p.2545-2559 [Peer Reviewed Journal]

Copyright © 2008 Massachusetts Medical Society. All rights reserved. ;2008 INIST-CNRS ;2008 Massachusetts Medical Society ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa0802743 ;PMID: 18539917 ;CODEN: NEJMAG

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Title:
Effects of Intensive Glucose Lowering in Type 2 Diabetes
Author: Gerstein, Hertzel C ; Miller, Michael E ; Byington, Robert P ; Goff, Jr, David C ; Bigger, J Thomas ; Buse, John B ; Cushman, William C ; Genuth, Saul ; Ismail-Beigi, Faramarz ; Grimm, Jr, Richard H ; Probstfield, Jeffrey L ; Simons-Morton, Denise G ; Friedewald, William T
Subjects: Adult ; Aged ; Biological and medical sciences ; Blood Glucose - analysis ; Blood sugar ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - epidemiology ; Care and treatment ; Diabetes ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - mortality ; Diabetes. Impaired glucose tolerance ; Drug Therapy, Combination ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Evaluation ; Female ; Follow-Up Studies ; General aspects ; Glucose ; Glycated Hemoglobin - analysis ; Humans ; Hyperglycemia ; Hypertension - complications ; Hypertension - drug therapy ; Hypoglycemia - chemically induced ; Hypoglycemic Agents - administration & dosage ; Hypoglycemic Agents - adverse effects ; Hypotheses ; Kaplan-Meier Estimate ; Male ; Medical sciences ; Metabolic disorders ; Middle Aged ; Mortality ; Proportional Hazards Models ; Risk factors ; Treatment Failure ; Type 2 diabetes
Is Part Of: The New England journal of medicine, 2008-06, Vol.358 (24), p.2545-2559
Description: Intensive glucose lowering targeting glycated hemoglobin levels of less than 6.0% was unexpectedly associated with an increase in overall mortality in high-risk patients with type 2 diabetes in the ACCORD trial. The findings identify a previously unrecognized risk of intensive glucose lowering in such patients. Intensive glucose lowering targeting glycated hemoglobin levels to less than 6.0% was unexpectedly associated with an increase in overall mortality in high-risk patients with type 2 diabetes. Type 2 diabetes mellitus is a metabolic disease that is diagnosed on the basis of sustained hyperglycemia. People with type 2 diabetes are at elevated risk for a number of serious health problems, including cardiovascular disease, premature death, blindness, kidney failure, amputations, fractures, frailty, depression, and cognitive decline. 1 In prospective epidemiologic studies, the incidence of many of these outcomes is directly associated with the degree of hyperglycemia, as measured by the plasma glucose or the glycated hemoglobin level, a measure of the mean blood glucose level during the previous 2 to 3 months. Thus, after adjustment for other risk factors, . . .
Publisher: Boston, MA: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
EISSN: 1533-4406
DOI: 10.1056/NEJMoa0802743
PMID: 18539917
CODEN: NEJMAG
Source: ProQuest One Psychology
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Effects of Intensive Glucose Lowering in Type 2 Diabetes

Copyright © 2008 Massachusetts Medical Society. All rights reserved. ;2008 INIST-CNRS ;2008 Massachusetts Medical Society ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa0802743 ;PMID: 18539917 ;CODEN: NEJMAG

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