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Sitting Time, Physical Activity, and Risk of Mortality in Adults

Journal of the American College of Cardiology, 2019-04, Vol.73 (16), p.2062-2072 [Tạp chí có phản biện]

2019 The Authors ;Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved. ;2019. The Authors ;ISSN: 0735-1097 ;EISSN: 1558-3597 ;DOI: 10.1016/j.jacc.2019.02.031 ;PMID: 31023430

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Nhan đề:
Sitting Time, Physical Activity, and Risk of Mortality in Adults
Tác giả: Stamatakis, Emmanuel ; Gale, Joanne ; Bauman, Adrian ; Ekelund, Ulf ; Hamer, Mark ; Ding, Ding
Chủ đề: Adults ; Age ; Age Factors ; Aged ; Behavior ; Cardiology ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - mortality ; Cardiovascular Diseases - physiopathology ; Cohort Studies ; Confidence intervals ; Diabetes ; epidemiology ; Ethics ; Exercise ; Female ; Health risks ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Mortality ; New South Wales ; Offsets ; Physical activity ; Physical Fitness ; Proportional Hazards Models ; Prospective Studies ; Public health ; Questionnaires ; Risk Assessment ; Sedentary Behavior ; Sex Factors ; Sitting Position ; Sleep ; Statistical analysis ; Studies ; Survival Analysis ; Time Factors ; Walking
Là 1 phần của: Journal of the American College of Cardiology, 2019-04, Vol.73 (16), p.2062-2072
Mô tả: It is unclear what level of moderate to vigorous intensity physical activity (MVPA) offsets the health risks of sitting. The purpose of this study was to examine the joint and stratified associations of sitting and MVPA with all-cause and cardiovascular disease (CVD) mortality, and to estimate the theoretical effect of replacing sitting time with physical activity, standing, and sleep. A longitudinal analysis of the 45 and Up Study calculated the multivariable-adjusted hazard ratios (HRs) of sitting for each sitting-MVPA combination group and within MVPA strata. Isotemporal substitution modeling estimated the per-hour HR effects of replacing sitting. A total of 8,689 deaths (1,644 due to CVD) occurred among 149,077 participants over an 8.9-year (median) follow-up. There was a statistically significant interaction between sitting and MVPA only for all-cause mortality. Sitting time was associated with both mortality outcomes in a nearly dose-response manner in the least active groups reporting <150 MVPA min/week. For example, among those reporting no MVPA, the all-cause mortality HR comparing the most sedentary (>8 h/day) to the least sedentary (<4 h/day) groups was 1.52 (95% confidence interval: 1.13 to 2.03). There was inconsistent and weak evidence for elevated CVD and all-cause mortality risks with more sitting among those meeting the lower (150 to 299 MVPA min/week) or upper (≥300 MVPA min/week) limits of the MVPA recommendation. Replacing sitting with walking and MVPA showed stronger associations among high sitters (>6 sitting h/day) where, for example, the per-hour CVD mortality HR for sitting replaced with vigorous activity was 0.36 (95% confidence interval: 0.17 to 0.74). Sitting is associated with all-cause and CVD mortality risk among the least physically active adults; moderate-to-vigorous physical activity doses equivalent to meeting the current recommendations attenuate or effectively eliminate such associations. [Display omitted]
Nơi xuất bản: United States: Elsevier Inc
Ngôn ngữ: English
Số nhận dạng: ISSN: 0735-1097
EISSN: 1558-3597
DOI: 10.1016/j.jacc.2019.02.031
PMID: 31023430
Nguồn: Freely Accessible Journals
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Sitting Time, Physical Activity, and Risk of Mortality in Adults

2019 The Authors ;Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved. ;2019. The Authors ;ISSN: 0735-1097 ;EISSN: 1558-3597 ;DOI: 10.1016/j.jacc.2019.02.031 ;PMID: 31023430

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