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Evaluation of the Spaceflight Cardiovascular Disease Risk using the Clinical Prediction Model Astro-Charm and the NASA Radiation Risk Model

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Title:
Evaluation of the Spaceflight Cardiovascular Disease Risk using the Clinical Prediction Model Astro-Charm and the NASA Radiation Risk Model
Author: Plante, I. ; Blattnig, Steve R. ; Little, Mark P. ; Khera, Amit ; Norman, Ryan B. ; Patel, Zarana S. ; Huff, Janice L.
Subjects: Aerospace Medicine ; Space Radiation
Description: Exposure to space radiation and other spaceflight hazards may pose an increased risk for cardiovascular diseases (CVD) during and after spaceflight [1], that should be quantified to plan future long-duration space missions such as the flight to Mars. The first CVD clinical prediction models (CPMs) for individuals were developed by the Framingham Heart Study investigators in the 1960’s. Since then, many CPMs have been developed and refined. The CPMs consider cardiovascular risk factors such as blood pressure, diabetes, cholesterol, and smoking. As there is a relationship between radiation-induced CVD risk and the background (non-exposed) CVD risk, it is possible to use CPMs to calculate a personalized risk for astronauts.
Publisher: Johnson Space Center
Language: English
Source: NASA Technical Reports Server

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