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Serious hazards of transfusion (SHOT) initiative: analysis of the first two annual reports

BMJ, 1999-07, Vol.319 (7201), p.16-19 [Peer Reviewed Journal]

1999 BMJ Publishing Group Ltd. ;1999 INIST-CNRS ;Copyright: 1999 (c) 1999 BMJ Publishing Group Ltd. ;Copyright © 1999, British Medical Journal 1999 ;ISSN: 0959-8138 ;ISSN: 0959-8146 ;EISSN: 1468-5833 ;EISSN: 1756-1833 ;DOI: 10.1136/bmj.319.7201.16 ;PMID: 10390452 ;CODEN: BMJOAE

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Title:
Serious hazards of transfusion (SHOT) initiative: analysis of the first two annual reports
Author: Williamson, L M ; Lowe, S ; Love, E M ; Cohen, H ; Soldan, K ; McClelland, D B L ; Skacel, P ; Barbara, J A J
Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Annual reports ; Biological and medical sciences ; Blood ; Blood banks ; Blood Component Transfusion - adverse effects ; Blood Component Transfusion - mortality ; Blood Group Incompatibility ; Blood grouping ; Blood transfusion ; Blood Transfusion - mortality ; Blood transfusions ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Cryoglobulins ; Error rates ; Erythrocyte Transfusion - adverse effects ; Erythrocyte Transfusion - mortality ; Health care ; Health hazards ; Humans ; Infections ; Ireland - epidemiology ; Job training ; Medical Errors - statistics & numerical data ; Medical sciences ; Plasma ; Platelet Transfusion - adverse effects ; Platelet Transfusion - mortality ; Platelets ; Population Surveillance ; Risk Management - statistics & numerical data ; Transfusion Reaction ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; United Kingdom - epidemiology
Is Part Of: BMJ, 1999-07, Vol.319 (7201), p.16-19
Description: Abstract Objective: To receive and collate reports of death or major complications of transfusion of blood or components. Design: Haematologists were invited confidentially to report deaths and major complications after blood transfusion during October 1996 to September 1998. Setting: Hospitals in United Kingdom and Ireland. Subjects: Patients who died or experienced serious complications, as defined below, associated with transfusion of red cells, platelets, fresh frozen plasma, or cryoprecipitate. Main outcome measures: Death, “wrong” blood transfused to patient, acute and delayed transfusion reactions, transfusion related acute lung injury, transfusion associated graft versus host disease, post-transfusion purpura, and infection transmitted by transfusion. Circumstances relating to these cases and relative frequency of complications. Results: Over 24 months, 366 cases were reported, of which 191 (52%) were “wrong blood to patient” episodes. Analysis of these revealed multiple errors of identification, often beginning when blood was collected from the blood bank. There were 22 deaths from all causes, including three from ABO incompatibility. There were 12 infections: four bacterial (one fatal), seven viral, and one fatal case of malaria. During the second 12 months, 164/424 hospitals (39%) submitted a “nil to report” return. Conclusions: Transfusion is now extremely safe, but vigilance is needed to ensure correct identification of blood and patient. Staff education should include awareness of ABO incompatibility and bacterial contamination as causes of life threatening reactions to blood. Key messages Blood transfusion, while extremely safe, has several potentially fatal hazards All staff handling blood should be aware of the importance of correct identity of sample, patient, and blood bag at all stages Resources should be directed to evaluation of methods for improving identification of patients Acute fever or collapse during or after transfusion may be due to ABO incompatibility or bacterial contamination Microbiological complications of transfusion accounted for a minor component of all reports
Publisher: London: British Medical Journal Publishing Group
Language: English
Identifier: ISSN: 0959-8138
ISSN: 0959-8146
EISSN: 1468-5833
EISSN: 1756-1833
DOI: 10.1136/bmj.319.7201.16
PMID: 10390452
CODEN: BMJOAE
Source: MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Serious hazards of transfusion (SHOT) initiative: analysis of the first two annual reports

1999 BMJ Publishing Group Ltd. ;1999 INIST-CNRS ;Copyright: 1999 (c) 1999 BMJ Publishing Group Ltd. ;Copyright © 1999, British Medical Journal 1999 ;ISSN: 0959-8138 ;ISSN: 0959-8146 ;EISSN: 1468-5833 ;EISSN: 1756-1833 ;DOI: 10.1136/bmj.319.7201.16 ;PMID: 10390452 ;CODEN: BMJOAE

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