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Responses of cutaneous C-fiber afferents and spinal microglia after hindlimb cast immobilization in rats

The journal of physiological sciences, 2021-06, Vol.71 (1), p.19-19, Article 19 [Peer Reviewed Journal]

COPYRIGHT 2021 Springer ;2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. ;The Author(s) 2021 ;ISSN: 1880-6546 ;EISSN: 1880-6562 ;DOI: 10.1186/s12576-021-00803-3 ;PMID: 34162322

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Title:
Responses of cutaneous C-fiber afferents and spinal microglia after hindlimb cast immobilization in rats
Author: Ota, Hiroki ; Takebe, Haruna ; Mizumura, Kazue ; Taguchi, Toru
Subjects: Animals ; Ankle ; Behavior ; Casts, Surgical - adverse effects ; Dorsal horn ; Experiments ; Fibers ; Heat stimuli ; Hindlimb - physiology ; Hypersensitivity ; Immobilization ; Immobilization - adverse effects ; Male ; Mathematical models ; Microglia ; Microglia - physiology ; Nerve Fibers, Unmyelinated - physiology ; Neurons, Afferent - physiology ; Nociception - physiology ; Original Paper ; Pain ; Pain Measurement ; Pain perception ; Rats ; Rats, Sprague-Dawley ; Saphenous nerve ; Skin - innervation ; Spinal cord ; Spinal Cord - physiology ; Statistical analysis
Is Part Of: The journal of physiological sciences, 2021-06, Vol.71 (1), p.19-19, Article 19
Description: Previous studies have shown that persistent limb immobilization using a cast increases nociceptive behavior to somatic stimuli in rats. However, the peripheral neural mechanisms of nociception remain unclear. Using single-fiber electrophysiological recordings in vitro, we examined the general characteristics of cutaneous C-fiber afferents in the saphenous nerve and their responsiveness to mechanical and heat stimuli in a rat model of immobilization-induced pain by subjecting the rats to hindlimb cast immobilization for 4 weeks. The mechanical response of C-fibers appeared to increase in the model; however, statistical analysis revealed that neither the response threshold nor the response magnitude was altered. The general characteristics and heat responses of the C-fibers were not altered. The number of microglia and cell diameters significantly increased in the superficial dorsal horn of the lumbar spinal cord. Thus, activated microglia-mediated spinal mechanisms are associated with the induction of nociceptive hypersensitivity in rats after persistent cast immobilization.
Publisher: Japan: Springer
Language: English
Identifier: ISSN: 1880-6546
EISSN: 1880-6562
DOI: 10.1186/s12576-021-00803-3
PMID: 34162322
Source: MEDLINE
ProQuest Central
DOAJ Directory of Open Access Journals

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Responses of cutaneous C-fiber afferents and spinal microglia after hindlimb cast immobilization in rats

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