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A case‐control study of brain structure and behavioral characteristics in 47,XXX syndrome

Genes, brain and behavior, 2014-11, Vol.13 (8), p.841-849 [Peer Reviewed Journal]

Published 2014. This article is a U.S. Government work and is in the public domain in the USA. ;ISSN: 1601-1848 ;EISSN: 1601-183X ;DOI: 10.1111/gbb.12180 ;PMID: 25287572 ;CODEN: GBBEAO

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Title:
A case‐control study of brain structure and behavioral characteristics in 47,XXX syndrome
Author: Lenroot, R. K. ; Blumenthal, J. D. ; Wallace, G. L. ; Clasen, L. S. ; Lee, N. R. ; Giedd, J. N.
Subjects: Adolescent ; adolescents ; Anxiety Disorders - complications ; Anxiety Disorders - pathology ; Anxiety Disorders - psychology ; Attention Deficit Disorder with Hyperactivity - complications ; Attention Deficit Disorder with Hyperactivity - pathology ; Attention Deficit Disorder with Hyperactivity - psychology ; Brain ; Brain - pathology ; Case-Control Studies ; Child ; Child, Preschool ; children ; Chromosomes, Human, X ; Depressive Disorder - complications ; Depressive Disorder - pathology ; Depressive Disorder - psychology ; Female ; Humans ; Magnetic Resonance Imaging ; Sex Chromosome Aberrations ; sex chromosome aneuploidy ; Sex Chromosome Disorders of Sex Development - complications ; Sex Chromosome Disorders of Sex Development - pathology ; Sex Chromosome Disorders of Sex Development - psychology ; Trisomy - pathology ; Trisomy X syndrome ; X chromosome ; XXX ; Young Adult
Is Part Of: Genes, brain and behavior, 2014-11, Vol.13 (8), p.841-849
Description: Trisomy X, the presence of an extra X chromosome in females (47,XXX), is a relatively common but under‐recognized chromosomal disorder associated with characteristic cognitive and behavioral features of varying severity. The objective of this study was to determine whether there were neuroanatomical differences in girls with Trisomy X that could relate to cognitive and behavioral differences characteristic of the disorder during childhood and adolescence. MRI scans were obtained on 35 girls with Trisomy X (mean age 11.4, SD 5.5) and 70 age‐ and sex‐matched healthy controls. Cognitive and behavioral testing was also performed. Trisomy X girls underwent a semi‐structured psychiatric interview. Regional brain volumes and cortical thickness were compared between the two groups. Total brain volume was significantly decreased in subjects with Trisomy X, as were all regional volumes with the exception of parietal gray matter. Differences in cortical thickness had a mixed pattern. The subjects with Trisomy X had thicker cortex in bilateral medial prefrontal cortex and right medial temporal lobe, but decreased cortical thickness in both lateral temporal lobes. The most common psychiatric disorders present in this sample of Trisomy X girls included anxiety disorders (40%), attention‐deficit disorder (17%) and depressive disorders (11%). The most strongly affected brain regions are consistent with phenotypic characteristics such as language delay, poor executive function and heightened anxiety previously described in population‐based studies of Trisomy X and also found in our sample. Differences in cortical thickness associated with an additional X chromosome in females (panels 1 and 2) and males (panel 3). Colored regions are significantly different after FDR correction for multiple comparisons. *Adapted from Giedd et al. ().
Publisher: Oxford, UK: Blackwell Publishing Ltd
Language: English
Identifier: ISSN: 1601-1848
EISSN: 1601-183X
DOI: 10.1111/gbb.12180
PMID: 25287572
CODEN: GBBEAO
Source: Journals@Ovid Open Access Journal Collection Rolling
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