skip to main content

Sign out
Sign in

Language:

Systemic lupus erythematosus in a multiethnic US Cohort (LUMINA). XXX: association between C-reactive protein (CRP) gene polymorphisms and vascular events

Rheumatology (Oxford, England), 2005-07, Vol.44 (7), p.864-868 [Peer Reviewed Journal]

2005 INIST-CNRS ;Copyright Oxford University Press(England) Jul 2005 ;ISSN: 1462-0324 ;EISSN: 1462-0332 ;DOI: 10.1093/rheumatology/keh613 ;PMID: 15797975 ;CODEN: BJRHDF

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Systemic lupus erythematosus in a multiethnic US Cohort (LUMINA). XXX: association between C-reactive protein (CRP) gene polymorphisms and vascular events
Author: Szalai, A. J. ; Alarcón, G. S. ; Calvo-Alén, J. ; Toloza, S. M. A. ; McCrory, M. A. ; Edberg, J. C. ; McGwin, G. ; Bastian, H. M. ; Fessler, B. J. ; Vilá, L. M. ; Kimberly, R. P. ; Reveille, J. D.
Subjects: Adult ; African Americans ; Biological and medical sciences ; C-reactive protein ; C-Reactive Protein - analysis ; C-Reactive Protein - genetics ; Cardiovascular Diseases - ethnology ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - genetics ; Case-Control Studies ; European Continental Ancestry Group ; Female ; Gene Frequency ; Hispanic Americans ; Humans ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - ethnology ; Lupus Erythematosus, Systemic - genetics ; Male ; Medical sciences ; Middle Aged ; Polymorphism, Genetic ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Systemic lupus erythematosus ; United States - epidemiology
Is Part Of: Rheumatology (Oxford, England), 2005-07, Vol.44 (7), p.864-868
Description: Objectives. To determine if a polymorphic GTn repeat in the intron of the C-reactive protein (CRP) gene associates with occurrence of vascular arterial events in systemic lupus erythematosus (SLE). Methods. We performed a nested case–control study on the LUMINA cohort of 546 Hispanic, African-American and Caucasian SLE patients. Twenty-five patients who developed vascular arterial events (i.e. myocardial infarction, angina, coronary artery bypass graft surgery, stroke, claudication, gangrene or significant tissue loss and/or arterial peripheral thrombosis) after enrolment were selected as cases and 32 ethnically matched patients with no previous vascular arterial events served as controls. Their CRP gene GTn polymorphism and plasma CRP was determined. Results. Patients with vascular events had more severe SLE and were more likely to have plasma CRP in the highest quintile of measured values. The overall distribution of GTn alleles for patients with vascular events had a greater number of the GT20 variant compared with controls [26.0% of alleles (13/50) vs 15.6% (10/64)]. This greater number of GT20 in patients with vascular events was observed for African-Americans [29.2% (7/24) vs 21.0% (8/38)] and Hispanics [33.0% (4/12) vs 0% (0/16)] but not for Caucasians [14.3% (2/14) vs 20.0% (2/10)]. For African-Americans and Hispanics combined (45 patients), the frequency of GT20 in those with vascular events (30.6%, 11/36) was significantly higher than in those without them (14.8%, 8/54) (P<0.05, one-tailed test for difference in proportions). When patients were categorized according to the number of GT20 alleles they carried (thus GT20/GT20, GT20/GTx or GTx/GTx, where x is any allele other than GT20), for both African-Americans and Hispanics the likelihood of vascular arterial events increased in proportion with the GT20 dose, and all GT20-homozygous patients developed vascular arterial events. Conclusions. The CRP GT20 variant is more likely to occur in African-American and Hispanic SLE patients than in Caucasian ones, and SLE patients carrying the GT20 allele are more likely to develop vascular arterial events.
Publisher: Oxford: Oxford University Press
Language: English
Identifier: ISSN: 1462-0324
EISSN: 1462-0332
DOI: 10.1093/rheumatology/keh613
PMID: 15797975
CODEN: BJRHDF
Source: MEDLINE
Alma/SFX Local Collection

Back to results list


	INSPIRE LIBRARY - TON DUC THANG UNIVERSITY		(84-028) 37 755 057	Feedback
	19 Nguyen Huu Tho St. Dist.7, HCM		thuvien@tdtu.edu.vn	Feedback

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait

Searching for
inscope:(TDTS),scope:(SFX),scope:(TDT),scope:(SEN),primo_central_multiple_fe
Show me what you have so far