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1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing

Molecules, 2016-11, Vol.21 (11), p.1600 [Peer Reviewed Journal]

Copyright MDPI AG 2016 ;2016 by the authors. 2016 ;ISSN: 1420-3049 ;EISSN: 1420-3049 ;DOI: 10.3390/molecules21111600 ;PMID: 27886092

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Title:
1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing
Author: Gao, Kuo ; Zheng, Chenglong ; Wang, Tong ; Zhao, Huihui ; Wang, Juan ; Wang, Zhiyong ; Zhai, Xing ; Jia, Zijun ; Chen, Jianxin ; Zhou, Yingwu ; Wang, Wei
Subjects: 1-Deoxynojirimycin - administration & dosage ; 1-Deoxynojirimycin - chemistry ; 1-Deoxynojirimycin - isolation & purification ; 1-Deoxynojirimycin - pharmacology ; Anti-Obesity Agents - administration & dosage ; Anti-Obesity Agents - isolation & purification ; Anti-Obesity Agents - pharmacology ; Antiviral Agents - administration & dosage ; Antiviral Agents - isolation & purification ; Antiviral Agents - pharmacology ; Bacillus - chemistry ; Chromatography, High Pressure Liquid ; Humans ; Hypoglycemic Agents - administration & dosage ; Hypoglycemic Agents - isolation & purification ; Hypoglycemic Agents - pharmacology ; Molecular Structure ; Morus - chemistry ; Plant Leaves - chemistry ; Review ; Streptomyces - chemistry
Is Part Of: Molecules, 2016-11, Vol.21 (11), p.1600
Description: 1-Deoxynojirimycin (DNJ, C₆H NO₄, 163.17 g/mol), an alkaloid azasugar or iminosugar, is a biologically active natural compound that exists in mulberry leaves and (dayflower) as well as from several bacterial strains such as and species. Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features. Therefore, the aim of this detailed review article is to summarize the existing knowledge on occurrence, extraction, purification, determination, chemistry, and bioactivities of DNJ, so that researchers may use it to explore future perspectives of research on DNJ. Moreover, possible molecular targets of DNJ will also be investigated using suitable in silico approach.
Publisher: Switzerland: MDPI AG
Language: English
Identifier: ISSN: 1420-3049
EISSN: 1420-3049
DOI: 10.3390/molecules21111600
PMID: 27886092
Source: Open Access: DOAJ Directory of Open Access Journals
Geneva Foundation Free Medical Journals at publisher websites
AUTh Library subscriptions: ProQuest Central
MEDLINE
PubMed Central
Alma/SFX Local Collection

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1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing

Copyright MDPI AG 2016 ;2016 by the authors. 2016 ;ISSN: 1420-3049 ;EISSN: 1420-3049 ;DOI: 10.3390/molecules21111600 ;PMID: 27886092

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