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Lesion location matters: The relationships between white matter hyperintensities on cognition in the healthy elderly

Journal of cerebral blood flow and metabolism, 2019-01, Vol.39 (1), p.36-43 [Peer Reviewed Journal]

The Author(s) 2017 ;The Author(s) 2017 2017 International Society for Cerebral Blood Flow and Metabolism ;ISSN: 0271-678X ;EISSN: 1559-7016 ;DOI: 10.1177/0271678X17740501 ;PMID: 29106319

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Title:
Lesion location matters: The relationships between white matter hyperintensities on cognition in the healthy elderly
Author: Lampe, Leonie ; Kharabian-Masouleh, Shahrzad ; Kynast, Jana ; Arelin, Katrin ; Steele, Christopher J ; Löffler, Markus ; Witte, A Veronica ; Schroeter, Matthias L ; Villringer, Arno ; Bazin, Pierre-Louis
Subjects: Aged ; Aged, 80 and over ; Aging - physiology ; Cerebral Small Vessel Diseases - diagnostic imaging ; Cerebral Small Vessel Diseases - pathology ; Cerebral Ventricles - diagnostic imaging ; Cerebral Ventricles - physiology ; Cognition - physiology ; Cognitive Dysfunction ; Executive Function - physiology ; Female ; Frontal Lobe - diagnostic imaging ; Frontal Lobe - physiology ; Healthy Volunteers ; Humans ; Magnetic Resonance Imaging ; Male ; Memory - physiology ; Middle Aged ; Neuropsychological Tests ; Original ; Psychomotor Performance - physiology ; Pyramidal Tracts - diagnostic imaging ; Pyramidal Tracts - physiology ; White Matter - diagnostic imaging ; White Matter - growth & development ; White Matter - physiology
Is Part Of: Journal of cerebral blood flow and metabolism, 2019-01, Vol.39 (1), p.36-43
Description: White matter hyperintensities (WMH) are associated with cognitive decline. We aimed to identify the spatial specificity of WMH impact on cognition in non-demented, healthy elderly. We quantified WMH volume among healthy participants of a community dwelling cohort (n = 702, age range 60 – 82 years, mean age = 69.5 years, 46% female) and investigated the effects of WMH on cognition and behavior, specifically for executive function, memory, and motor speed performance. Lesion location influenced their effect on cognition and behavior: Frontal WMH in the proximity of the frontal ventricles mainly affected executive function and parieto-temporal WMH in the proximity of the posterior horns deteriorated memory, while WMH in the upper deep white matter—including the corticospinal tract—compromised motor speed performance. This study exposes the subtle and subclinical yet detrimental effects of WMH on cognition in healthy elderly, and strongly suggests a causal influence of WMH on cognition by demonstrating the spatial specificity of these effects.
Publisher: London, England: SAGE Publications
Language: English
Identifier: ISSN: 0271-678X
EISSN: 1559-7016
DOI: 10.1177/0271678X17740501
PMID: 29106319
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central

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Lesion location matters: The relationships between white matter hyperintensities on cognition in the healthy elderly

The Author(s) 2017 ;The Author(s) 2017 2017 International Society for Cerebral Blood Flow and Metabolism ;ISSN: 0271-678X ;EISSN: 1559-7016 ;DOI: 10.1177/0271678X17740501 ;PMID: 29106319

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