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Cancer Mortality in Workers Exposed to Organochlorine Compounds in the Pulp and Paper Industry: An International Collaborative Study

Environmental health perspectives, 2006-07, Vol.114 (7), p.1007-1012 [Peer Reviewed Journal]

COPYRIGHT 2006 National Institute of Environmental Health Sciences ;Copyright National Institute of Environmental Health Sciences Jul 2006 ;2006 ;ISSN: 0091-6765 ;ISSN: 1552-9924 ;EISSN: 1552-9924 ;DOI: 10.1289/ehp.8588 ;PMID: 16835051

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Title:
Cancer Mortality in Workers Exposed to Organochlorine Compounds in the Pulp and Paper Industry: An International Collaborative Study
Author: McLean, David ; Pearce, Neil ; Langseth, Hilde ; Jäppinen, Paavo ; Szadkowska-Stanczyk, Irena ; Persson, Bodil ; Wild, Pascal ; Kishi, Reiko ; Lynge, Elsebeth ; Henneberger, Paul ; Sala, Maria ; Teschke, Kay ; Kauppinen, Timo ; Colin, Didier ; Kogevinas, Manolis ; Boffetta, Paolo
Subjects: Asbestos ; Cancer ; Chemical hazards ; Chlorinated hydrocarbons ; Cohort studies ; Death ; Epidemiology ; Health aspects ; Hodgkin disease ; Humans ; Hydrocarbons, Chlorinated - administration & dosage ; Hydrocarbons, Chlorinated - toxicity ; MEDICIN ; MEDICINE ; Mortality ; Neoplasms ; Neoplasms - chemically induced ; Neoplasms - mortality ; Occupational Diseases - chemically induced ; Occupational Diseases - mortality ; Occupational Exposure ; Oncology, Experimental ; Organochlorines ; Paper industry ; Pulp and paper industry ; Pulp industry ; Risk Factors ; Statistical significance ; Time Factors ; Workers
Is Part Of: Environmental health perspectives, 2006-07, Vol.114 (7), p.1007-1012
Description: The objective of this study was to evaluate cancer mortality in pulp and paper industry workers exposed to chlorinated organic compounds. We assembled a multinational cohort of workers employed between 1920 and 1996 in 11 countries. Exposure to both volatile and nonvolatile organochlorine compounds was estimated at the department level using an exposure matrix. We conducted a standardized mortality ratio (SMR) analysis based on age and calendar-period-specific national mortality rates and a Poisson regression analysis. The study population consisted of 60,468 workers. Workers exposed to volatile organochlorines experienced a deficit of all-cause [SMR = 0.91; 95% confidence interval (CI), 0.89-0.93] and all-cancer (SMR = 0.93; 95% CI, 0.89-0.97) mortality, with no evidence of increased risks for any cancer of a priori interest. There was a weak, but statistically significant, trend of increasing risk of all-cancer mortality with increasing weighted cumulative exposure. A similar deficit in all-cause (SMR = 0.94; 95% CI, 0.91-0.96) and all-cancer (SMR = 0.94; 95% CI, 0.89-1.00) mortality was observed in those exposed to nonvolatile organochlorines. No excess risk was observed in cancers of a priori interest, although mortality from Hodgkin disease was elevated (SMR = 1.76; 95% CI, 1.02-2.82). In this study we found little evidence that exposure to organochlorines at the levels experienced in the pulp and paper industry is associated with an increased risk of cancer, apart from a weak but significant association between all-cancer mortality and weighted cumulative volatile organochlorine exposure.
Publisher: United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare
Language: English
Identifier: ISSN: 0091-6765
ISSN: 1552-9924
EISSN: 1552-9924
DOI: 10.1289/ehp.8588
PMID: 16835051
Source: U.S. Government Documents
MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Cancer Mortality in Workers Exposed to Organochlorine Compounds in the Pulp and Paper Industry: An International Collaborative Study

COPYRIGHT 2006 National Institute of Environmental Health Sciences ;Copyright National Institute of Environmental Health Sciences Jul 2006 ;2006 ;ISSN: 0091-6765 ;ISSN: 1552-9924 ;EISSN: 1552-9924 ;DOI: 10.1289/ehp.8588 ;PMID: 16835051

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