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Characteristics of diabetic macular edema patients with serous retinal detachment

Medicine (Baltimore), 2019-12, Vol.98 (51), p.e18333-e18333 [Peer Reviewed Journal]

Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. 2019 ;ISSN: 0025-7974 ;EISSN: 1536-5964 ;DOI: 10.1097/MD.0000000000018333 ;PMID: 31860985

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Title:
Characteristics of diabetic macular edema patients with serous retinal detachment
Author: Hwang, Hyung Bin ; Jee, Donghyun ; Kwon, Jin-Woo
Subjects: Angiogenesis Inhibitors - therapeutic use ; Aqueous Humor - metabolism ; Bevacizumab - therapeutic use ; Case-Control Studies ; Diabetic Retinopathy - drug therapy ; Diabetic Retinopathy - metabolism ; Female ; Humans ; Interleukin-1beta - metabolism ; Intravitreal Injections ; Macular Edema - drug therapy ; Macular Edema - metabolism ; Male ; Middle Aged ; Observational Study ; Placenta Growth Factor - metabolism ; Prognosis ; Retina - pathology ; Retinal Detachment - drug therapy ; Retinal Detachment - metabolism ; Vascular Endothelial Growth Factor A - metabolism ; Visual Acuity - drug effects
Is Part Of: Medicine (Baltimore), 2019-12, Vol.98 (51), p.e18333-e18333
Description: To determine characteristics of diabetic macular edema patients with serous retinal detachment (SRD).We classified naïve diabetic macular edema (DME) patients with or without SRD, and compared their baseline characteristics; intravitreal bevacizumab (IVB) responsiveness; aqueous concentrations of IL (interleukin)-1β, -2, -8, -10, -17, placental growth factor (PlGF), and vascular endothelial growth factor (VEGF). In addition, factors associated with the existence of SRD were identified.Of the 64 DME patients, 14 had SRD. The average levels of aqueous VEGF and PlGF were significantly higher in the SRD group than in the control group (P = .022 and P = .041, respectively). The best-corrected visual acuity (BCVA) and central subfield thickness (CST) did not differ significantly between the 2 groups at baseline or after 3 consecutive monthly IVBs. In multivariate logistic regression analysis, the level of aqueous VEGF was the only factor associated with the existence of SRD (odds ratio: 1.03; P = .038).Rather than aqueous inflammatory cytokines, levels of aqueous VEGFs were associated with the occurrence of SRD in DME patients. In terms of prognosis, the existence of SRD was not related with BCVA or CST changes.
Publisher: United States: Wolters Kluwer Health
Language: English
Identifier: ISSN: 0025-7974
EISSN: 1536-5964
DOI: 10.1097/MD.0000000000018333
PMID: 31860985
Source: Journals@Ovid Open Access Journal Collection Rolling
Wolters Kluwer Open Health
MEDLINE
PubMed Central
DOAJ Directory of Open Access Journals
IngentaConnect Open Access Journals

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Characteristics of diabetic macular edema patients with serous retinal detachment

Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. 2019 ;ISSN: 0025-7974 ;EISSN: 1536-5964 ;DOI: 10.1097/MD.0000000000018333 ;PMID: 31860985

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