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Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States

BMJ (Online), 2014-06, Vol.348 (7963), p.g3656-g3656 [Peer Reviewed Journal]

Schöttker et al 2014 ;Schöttker et al 2014. ;Copyright: 2014 © Schöttker et al 2014 ;info:eu-repo/semantics/openAccess ;Schöttker et al 2014 2014 Schöttker et al ;Wageningen University & Research ;ISSN: 0959-8138 ;ISSN: 1756-1833 ;ISSN: 0959-8146 ;EISSN: 1756-1833 ;DOI: 10.1136/bmj.g3656 ;PMID: 24938302 ;CODEN: BMJOAE

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Title:
Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States
Author: Schöttker, Ben ; Jorde, Rolf ; Peasey, Anne ; Thorand, Barbara ; Jansen, Eugène H J M ; Groot, Lisette de ; Streppel, Martinette ; Gardiner, Julian ; Ordóñez-Mena, José Manuèl ; Perna, Laura ; Wilsgaard, Tom ; Rathmann, Wolfgang ; Feskens, Edith ; Kampman, Ellen ; Siganos, Galatios ; Njølstad, Inger ; Mathiesen, Ellisiv Bøgeberg ; Kubínová, Růžena ; Pająk, Andrzej ; Topor-Madry, Roman ; Tamosiunas, Abdonas ; Hughes, Maria ; Kee, Frank ; Bobak, Martin ; Trichopoulou, Antonia ; Boffetta, Paolo ; Brenner, Hermann
Subjects: 25-Hydroxyvitamin D ; Age ; Age Factors ; Aged ; all-cause mortality ; Blood ; Cancer ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - mortality ; cardiovascular-disease ; Cohort analysis ; Cohort Studies ; Cultural differences ; epidemiology ; Europe ; Female ; general-population ; Humans ; intervention ; Longevity ; Male ; Meta-analysis ; Middle Aged ; monica/kora augsburg ; Mortality ; Neoplasms - blood ; Neoplasms - mortality ; Nutrition ; older-adults ; risk ; Risk factors ; Seasons ; Serum ; serum 25-hydroxyvitamin d ; Sex ; Sex Factors ; Studies ; Supplementation ; United States ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D Deficiency - complications ; Vitamin D Deficiency - mortality
Is Part Of: BMJ (Online), 2014-06, Vol.348 (7963), p.g3656-g3656
Description: Objective To investigate the association between serum 25-hydroxyvitamin D concentrations (25(OH)D) and mortality in a large consortium of cohort studies paying particular attention to potential age, sex, season, and country differences.Design Meta-analysis of individual participant data of eight prospective cohort studies from Europe and the US.Setting General population.Participants 26 018 men and women aged 50-79 yearsMain outcome measures All-cause, cardiovascular, and cancer mortality.Results 25(OH)D concentrations varied strongly by season (higher in summer), country (higher in US and northern Europe) and sex (higher in men), but no consistent trend with age was observed. During follow-up, 6695 study participants died, among whom 2624 died of cardiovascular diseases and 2227 died of cancer. For each cohort and analysis, 25(OH)D quintiles were defined with cohort and subgroup specific cut-off values. Comparing bottom versus top quintiles resulted in a pooled risk ratio of 1.57 (95% CI 1.36 to 1.81) for all-cause mortality. Risk ratios for cardiovascular mortality were similar in magnitude to that for all-cause mortality in subjects both with and without a history of cardiovascular disease at baseline. With respect to cancer mortality, an association was only observed among subjects with a history of cancer (risk ratio, 1.70 (1.00 to 2.88)). Analyses using all quintiles suggest curvilinear, inverse, dose-response curves for the aforementioned relationships. No strong age, sex, season, or country specific differences were detected. Heterogeneity was low in most meta-analyses.Conclusions Despite levels of 25(OH)D strongly varying with country, sex, and season, the association between 25(OH)D level and all-cause and cause-specific mortality was remarkably consistent. Results from a long term randomised controlled trial addressing longevity are being awaited before vitamin D supplementation can be recommended in most individuals with low 25(OH)D levels.
Publisher: England: British Medical Journal Publishing Group
Language: English
Identifier: ISSN: 0959-8138
ISSN: 1756-1833
ISSN: 0959-8146
EISSN: 1756-1833
DOI: 10.1136/bmj.g3656
PMID: 24938302
CODEN: BMJOAE
Source: BMJ Open Access Journals
MEDLINE
NORA Norwegian Open Research Archives
ProQuest Central

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Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States

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