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Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders

The journal of venomous animals and toxins including tropical diseases, 2015-08, Vol.21 (1), p.31-31, Article 31 [Peer Reviewed Journal]

COPYRIGHT 2015 BioMed Central Ltd. ;COPYRIGHT 2015 BioMed Central Ltd. ;Copyright BioMed Central 2015 ;Monge-Fuentes et al. 2015 ;This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 International License. ;ISSN: 1678-9199 ;ISSN: 1678-9180 ;EISSN: 1678-9199 ;DOI: 10.1186/s40409-015-0031-x ;PMID: 26257776

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  • Title:
    Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders
  • Author: Monge-Fuentes, Victoria ; Gomes, Flávia Maria Medeiros ; Campos, Gabriel Avohay Alves ; Silva, Juliana de Castro ; Biolchi, Andréia Mayer ; Dos Anjos, Lilian Carneiro ; Gonçalves, Jacqueline Coimbra ; Lopes, Kamila Soares ; Mortari, Márcia Renata
  • Subjects: Alzheimer's disease ; Arthropoda ; Care and treatment ; Epilepsy ; Health aspects ; Mediation ; Medical research ; Medicine, Experimental ; Nervous system diseases ; Neurons ; Review ; Stroke (Disease) ; TOXICOLOGY ; TROPICAL MEDICINE ; Type 2 diabetes ; Venom
  • Is Part Of: The journal of venomous animals and toxins including tropical diseases, 2015-08, Vol.21 (1), p.31-31, Article 31
  • Description: The impact of neurological disorders in society is growing with alarming estimations for an incidence increase in the next decades. These disorders are generally chronic and can affect individuals early during productive life, imposing real limitations on the performance of their social roles. Patients can have their independence, autonomy, freedom, self-image, and self-confidence affected. In spite of their availability, drugs for the treatment of these disorders are commonly associated with side effects, which can vary in frequency and severity. Currently, no effective cure is known. Nowadays, the biopharmaceutical research community widely recognizes arthropod venoms as a rich source of bioactive compounds, providing a plethora of possibilities for the discovery of new neuroactive compounds, opening up novel and attractive opportunities in this field. Several identified molecules with a neuropharmacological profile can act in the central nervous system on different neuronal targets, rendering them useful tools for the study of neurological disorders. In this context, this review aims to describe the current main compounds extracted from arthropod venoms for the treatment of five major existing neurological disorders: stroke, Alzheimer's disease, epilepsy, Parkinson's disease, and pathological anxiety.
  • Publisher: Brazil: BioMed Central Ltd
  • Language: English;Portuguese
  • Identifier: ISSN: 1678-9199
    ISSN: 1678-9180
    EISSN: 1678-9199
    DOI: 10.1186/s40409-015-0031-x
    PMID: 26257776
  • Source: SciELO
    DOAJ Directory of Open Access Journals
    GFMER Free Medical Journals
    PubMed Central
    ProQuest Central
    Springer Nature OA Free Journals
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