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Association of plasma-soluble ST2 and galectin-3 with cardiovascular events and mortality following cardiac surgery

The American heart journal, 2020-02, Vol.220, p.253-263 [Peer Reviewed Journal]

2019 ;Crown Copyright © 2019. Published by Elsevier Inc. All rights reserved. ;Copyright Elsevier Limited Feb 2020 ;ISSN: 0002-8703 ;EISSN: 1097-6744 ;DOI: 10.1016/j.ahj.2019.11.014 ;PMID: 31911262

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Title:
Association of plasma-soluble ST2 and galectin-3 with cardiovascular events and mortality following cardiac surgery
Author: Patel, Dipal M. ; Thiessen-Philbrook, Heather ; Brown, Jeremiah R. ; McArthur, Eric ; Moledina, Dennis G. ; Mansour, Sherry G. ; Shlipak, Michael G. ; Koyner, Jay L. ; Kavsak, Peter ; Whitlock, Richard P. ; Everett, Allen D. ; Malenka, David J. ; Garg, Amit X. ; Coca, Steven G. ; Parikh, Chirag R.
Subjects: Acute coronary syndromes ; Acute Kidney Injury - blood ; Acute Kidney Injury - etiology ; Aged ; Biomarkers ; Biomarkers - blood ; Cardiac Surgical Procedures - adverse effects ; Cardiac Surgical Procedures - mortality ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - mortality ; Cause of Death ; Cohort Studies ; Congestive heart failure ; Consortia ; Coronary Artery Bypass - adverse effects ; Female ; Fibrosis ; Galectin 3 - blood ; Galectin-3 ; Health risk assessment ; Heart attacks ; Heart failure ; Heart surgery ; Heart Valve Prosthesis Implantation - adverse effects ; Hemodynamics ; Humans ; Interleukin-1 Receptor-Like 1 Protein - blood ; Lung diseases ; Male ; Measurement methods ; Morbidity ; Mortality ; Myocardium ; Patients ; Postoperative Complications - blood ; Postoperative Complications - etiology ; Postoperative Complications - mortality ; Prospective Studies ; Surgery ; Thoracic surgery ; Tumorigenicity ; Ventricular Remodeling
Is Part Of: The American heart journal, 2020-02, Vol.220, p.253-263
Description: Cardiac surgery induces hemodynamic stress on the myocardium, and this process can be associated with significant post-operative morbidity and mortality. Soluble suppression of tumorigenicity 2 (sST2) and galectin-3 (gal-3) are biomarkers of myocardial remodeling and fibrosis; however, their potential association with post-operative changes is unknown. We measured peri-operative plasma sST2 and gal-3 levels in two prospective cohorts (TRIBE-AKI and NNE) of over 1800 patients who underwent cardiac surgery. sST2 and gal-3 levels were evaluated for association with a composite primary outcome of cardiovascular event or mortality over median follow-up periods of 3.4 and 6.0 years, respectively, for the two cohorts. Meta-analysis of hazard ratio estimates from the cohorts was performed using random effects models. Cohorts demonstrated event rates of 70.2 and 66.8 per 1000 person-years for the primary composite outcome. After adjustment for clinical covariates, higher post-operative sST2 and gal-3 levels were significantly associated with cardiovascular event or mortality [pooled estimate HRs: sST2 1.29 (95% CI 1.16, 1.44); gal-3 1.26 (95% CI 1.09, 1.46)]. These associations were not significantly modified by pre-operative congestive heart failure or AKI. Higher post-operative sST2 and gal-3 values were associated with increased incidence of cardiovascular event or mortality. These two biomarkers should be further studied for potential clinical utility for patients undergoing cardiac surgery. [Display omitted]
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0002-8703
EISSN: 1097-6744
DOI: 10.1016/j.ahj.2019.11.014
PMID: 31911262
Source: MEDLINE
ProQuest Central

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Association of plasma-soluble ST2 and galectin-3 with cardiovascular events and mortality following cardiac surgery

2019 ;Crown Copyright © 2019. Published by Elsevier Inc. All rights reserved. ;Copyright Elsevier Limited Feb 2020 ;ISSN: 0002-8703 ;EISSN: 1097-6744 ;DOI: 10.1016/j.ahj.2019.11.014 ;PMID: 31911262

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