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A Role of Drd2 Hippocampal Neurons in Context-Dependent Food Intake

Neuron (Cambridge, Mass.), 2019-05, Vol.102 (4), p.873-886.e5 [Peer Reviewed Journal]

2019 Elsevier Inc. ;Copyright © 2019 Elsevier Inc. All rights reserved. ;2019. Elsevier Inc. ;ISSN: 0896-6273 ;EISSN: 1097-4199 ;DOI: 10.1016/j.neuron.2019.03.011 ;PMID: 30930044

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Title:
A Role of Drd2 Hippocampal Neurons in Context-Dependent Food Intake
Author: Azevedo, Estefania P. ; Pomeranz, Lisa ; Cheng, Jia ; Schneeberger, Marc ; Vaughan, Roger ; Stern, Sarah A. ; Tan, Bowen ; Doerig, Katherine ; Greengard, Paul ; Friedman, Jeffrey M.
Subjects: Animals ; Association Learning - physiology ; Associative learning ; Behavior ; Behavior, Animal ; Brain ; Cognitive ability ; Cortex (entorhinal) ; Cues ; Data analysis ; Dopamine D2 receptors ; dopamine receptor 2 ; Entorhinal Cortex - physiology ; Experiments ; feeding ; Feeding behavior ; Feeding Behavior - physiology ; Food ; Food availability ; Food intake ; Hippocampus ; Hippocampus - cytology ; Hippocampus - physiology ; Memory ; Mice ; Neural Pathways - physiology ; Neurons ; Neurons - metabolism ; Neurons - physiology ; optogenetics ; Receptors, Dopamine D2 - metabolism ; Septum of Brain - physiology ; Software ; Spatial memory ; Spatial Memory - physiology ; Statistical analysis
Is Part Of: Neuron (Cambridge, Mass.), 2019-05, Vol.102 (4), p.873-886.e5
Description: Associative learning of food cues that link location in space to food availability guides feeding behavior in mammals. However, the function of specific neurons that are elements of the higher-order, cognitive circuitry controlling feeding behavior is largely unexplored. Here, we report that hippocampal dopamine 2 receptor (hD2R) neurons are specifically activated by food and that both acute and chronic modulation of their activity reduces food intake in mice. Upstream projections from the lateral entorhinal cortex (LEC) to the hippocampus activate hD2R cells and can also decrease food intake. Finally, activation of hD2R neurons interferes with the encoding of a spatial memory linking food to a specific location via projections from the hippocampus to the septal area. Altogether these data describe a previously unidentified LEC > hippocampus > septal higher-order circuit that regulates feeding behavior. [Display omitted] •Hippocampal Dopamine 2 Receptor (hD2R) neurons are activated by food cues•hD2R neurons connect with the entorhinal cortex (LEC) and the septal area (SA)•The LEC-hD2R-SA circuit decreases food intake in mice•hD2R cells activation influences food-place, but not object-place, associations Azevedo et al. identify a subpopulation of neurons expressing the dopamine receptor 2 (D2R) within the hippocampus that is activated by food. They show that these neurons regulate food intake and the encoding of a food-place memory.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0896-6273
EISSN: 1097-4199
DOI: 10.1016/j.neuron.2019.03.011
PMID: 30930044
Source: Cell Press Free Archives
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A Role of Drd2 Hippocampal Neurons in Context-Dependent Food Intake

2019 Elsevier Inc. ;Copyright © 2019 Elsevier Inc. All rights reserved. ;2019. Elsevier Inc. ;ISSN: 0896-6273 ;EISSN: 1097-4199 ;DOI: 10.1016/j.neuron.2019.03.011 ;PMID: 30930044

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