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Anti-Müllerian hormone level may predict successful pregnancy after adenomyomectomy in patients with infertility due to adenomyosis

Medicine (Baltimore), 2021-05, Vol.100 (21), p.e26075-e26075 [Peer Reviewed Journal]

Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. ;Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. 2021 ;ISSN: 0025-7974 ;EISSN: 1536-5964 ;DOI: 10.1097/MD.0000000000026075 ;PMID: 34032737

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Title:
Anti-Müllerian hormone level may predict successful pregnancy after adenomyomectomy in patients with infertility due to adenomyosis
Author: Won, Seyeon ; Hwang, Ji Young ; Lee, Nara ; Kim, Miseon ; Kim, Mi Kyoung ; Kim, Mi-La ; Yun, Bo Seong ; Seong, Seok Ju ; Jung, Yong Wook
Subjects: Adenomyosis - blood ; Adenomyosis - complications ; Adenomyosis - pathology ; Adenomyosis - surgery ; Adult ; Anti-Mullerian Hormone - blood ; Endometrium - pathology ; Endometrium - surgery ; Female ; Fertilization in Vitro - statistics & numerical data ; Humans ; Infertility, Female - blood ; Infertility, Female - etiology ; Infertility, Female - therapy ; Myometrium - pathology ; Myometrium - surgery ; Observational Study ; Ovarian Reserve ; Pregnancy ; Pregnancy Rate ; Prognosis ; Retrospective Studies ; Treatment Outcome
Is Part Of: Medicine (Baltimore), 2021-05, Vol.100 (21), p.e26075-e26075
Description: We aimed to determine clinical factors predicting successful pregnancy by comparing pregnancy failure and success groups after adenomyomectomy. Additionally, we analyzed fertility outcomes after adenomyomectomy.The medical records of 43 patients who had undergone adenomyomectomy and received in vitro fertilization treatment from 2017 to 2020 were retrospectively reviewed. Patients were divided into pregnancy failure (n = 28) and pregnancy success (n = 15) groups. Patients' demographic factors were evaluated and compared between the groups.The age of patients was higher (39.0 [32.0-45.0] vs. 37.0 [33.0-42.0] years, P = .006) whereas the level of anti-Müllerian hormone (anti-Müllerian hormone [AMH]; 0.54 [0.01-8.54] vs. 2.91 [0.34-7.92] ng/mL, P = .002) lower in the pregnancy failure group compared to the pregnancy success group. The operative time was longer (220.0 [68.0-440.0] vs. 175.0 [65.0-305.0] min, P = .048) while the estimated blood loss higher (750 [100-2500] vs. 500 [50-2000] mL, P = .016) in the pregnancy failure group compared to the pregnancy success group. No significant difference was observed in body mass index, symptoms, cancer antigen 125, preoperative uterine volume, or type of adenomyosis. In the multivariate analysis, age and AMH were significant predictive factors for successful pregnancy.Ovarian reserve (age and AMH) and disease severity might be predictive factors for successful pregnancy in patients who have undergone adenomyomectomy. Adenomyomectomy should be considered for women desiring pregnancy and having appropriate ovarian reserve. Our results would be beneficial for patients and clinicians before deciding on adenomyomectomy. Larger prospective studies are required to confirm our findings.
Publisher: United States: Lippincott Williams & Wilkins
Language: English
Identifier: ISSN: 0025-7974
EISSN: 1536-5964
DOI: 10.1097/MD.0000000000026075
PMID: 34032737
Source: IngentaConnect Open Access
Journals@Ovid Open Access Journal Collection Rolling
Wolters Kluwer Open Health
MEDLINE
PubMed Central
DOAJ Directory of Open Access Journals

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Anti-Müllerian hormone level may predict successful pregnancy after adenomyomectomy in patients with infertility due to adenomyosis

Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. ;Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. 2021 ;ISSN: 0025-7974 ;EISSN: 1536-5964 ;DOI: 10.1097/MD.0000000000026075 ;PMID: 34032737

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