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Neuroimaging effects of prenatal alcohol exposure on the developing human brain: a magnetic resonance imaging review

Acta neuropsychiatrica, 2015-10, Vol.27 (5), p.251-269 [Peer Reviewed Journal]

Scandinavian College of Neuropsychopharmacology 2015 ;ISSN: 0924-2708 ;EISSN: 1601-5215 ;DOI: 10.1017/neu.2015.12 ;PMID: 25780875

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Title:
Neuroimaging effects of prenatal alcohol exposure on the developing human brain: a magnetic resonance imaging review
Author: Donald, Kirsten Ann ; Eastman, Emma ; Howells, Fleur Margaret ; Adnams, Colleen ; Riley, Edward Patrick ; Woods, Roger Paul ; Narr, Katherine Louise ; Stein, Dan Joseph
Subjects: Adolescent ; Age ; Alcohol Drinking - adverse effects ; Brain ; Brain - drug effects ; Brain - embryology ; Brain - growth & development ; Brain - pathology ; Child ; Diffusion Magnetic Resonance Imaging - methods ; Diffusion Tensor Imaging ; Disability ; Female ; Fetal Alcohol Spectrum Disorders - pathology ; Fetal alcohol syndrome ; Humans ; Image Processing, Computer-Assisted ; Infant ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Medical imaging ; Neuroimaging ; Neuroimaging - methods ; Pregnancy ; Prenatal Exposure Delayed Effects - etiology ; Prenatal Exposure Delayed Effects - pathology ; Review Article ; Spectrum analysis ; Substance-Related Disorders - pathology ; Substance-Related Disorders - psychology
Is Part Of: Acta neuropsychiatrica, 2015-10, Vol.27 (5), p.251-269
Description: This paper reviews the magnetic resonance imaging (MRI) literature on the effects of prenatal alcohol exposure on the developing human brain. A literature search was conducted through the following databases: PubMed, PsycINFO and Google Scholar. Combinations of the following search terms and keywords were used to identify relevant studies: 'alcohol', 'fetal alcohol spectrum disorders', 'fetal alcohol syndrome', 'FAS', 'FASD', 'MRI', 'DTI', 'MRS', 'neuroimaging', 'children' and 'infants'. A total of 64 relevant articles were identified across all modalities. Overall, studies reported smaller total brain volume as well as smaller volume of both the white and grey matter in specific cortical regions. The most consistently reported structural MRI findings were alterations in the shape and volume of the corpus callosum, as well as smaller volume in the basal ganglia and hippocampi. The most consistent finding from diffusion tensor imaging studies was lower fractional anisotropy in the corpus callosum. Proton magnetic resonance spectroscopy studies are few to date, but showed altered neurometabolic profiles in the frontal and parietal cortex, thalamus and dentate nuclei. Resting-state functional MRI studies reported reduced functional connectivity between cortical and deep grey matter structures. Discussion There is a critical gap in the literature of MRI studies in alcohol-exposed children under 5 years of age across all MRI modalities. The dynamic nature of brain maturation and appreciation of the effects of alcohol exposure on the developing trajectory of the structural and functional network argue for the prioritisation of studies that include a longitudinal approach to understanding this spectrum of effects and potential therapeutic time points.
Publisher: Cambridge, UK: Cambridge University Press
Language: English;Dutch
Identifier: ISSN: 0924-2708
EISSN: 1601-5215
DOI: 10.1017/neu.2015.12
PMID: 25780875
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

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Neuroimaging effects of prenatal alcohol exposure on the developing human brain: a magnetic resonance imaging review

Scandinavian College of Neuropsychopharmacology 2015 ;ISSN: 0924-2708 ;EISSN: 1601-5215 ;DOI: 10.1017/neu.2015.12 ;PMID: 25780875

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