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Mendelian Randomization Study of ACLY and Cardiovascular Disease

The New England journal of medicine, 2019-03, Vol.380 (11), p.1033-1042 [Peer Reviewed Journal]

Copyright © 2019 Massachusetts Medical Society. All rights reserved. ;Copyright © 2019 Massachusetts Medical Society. ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1806747 ;PMID: 30865797

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Title:
Mendelian Randomization Study of ACLY and Cardiovascular Disease
Author: Ference, Brian A ; Ray, Kausik K ; Catapano, Alberico L ; Ference, Thatcher B ; Burgess, Stephen ; Neff, David R ; Oliver-Williams, Clare ; Wood, Angela M ; Butterworth, Adam S ; Di Angelantonio, Emanuele ; Danesh, John ; Kastelein, John J.P ; Nicholls, Stephen J
Subjects: Acids ; ATP Citrate (pro-S)-Lyase - antagonists & inhibitors ; ATP Citrate (pro-S)-Lyase - genetics ; Biomarkers ; Biomedical research ; Cancer ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - genetics ; Care and treatment ; Cholesterol ; Cholesterol, LDL ; Cholesterol, LDL - blood ; Citric acid ; Coenzyme A ; Control ; Coronary vessels ; Councils ; Diabetes ; Diabetes Mellitus - genetics ; Dicarboxylic Acids - pharmacology ; Dicarboxylic Acids - therapeutic use ; Drug therapy ; Fatty Acids - pharmacology ; Fatty Acids - therapeutic use ; Female ; Genetic aspects ; Genetic Predisposition to Disease ; Genetic variance ; Grants ; Health aspects ; Health risk assessment ; Heart attacks ; Humans ; Hydroxymethylglutaryl CoA Reductases - genetics ; Hydroxymethylglutaryl-CoA reductase ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Hypercholesterolemia - drug therapy ; Hypolipidemic Agents - pharmacology ; Hypolipidemic Agents - therapeutic use ; Lipids ; Lipoproteins - blood ; Low density lipoprotein ; Male ; Medical research ; Membrane Proteins - genetics ; Membrane Transport Proteins ; Mendelian Randomization Analysis ; Middle Aged ; Neoplasms - genetics ; Odds Ratio ; Plasma ; Risk ; Risk factors ; Statins ; Triglycerides - blood
Is Part Of: The New England journal of medicine, 2019-03, Vol.380 (11), p.1033-1042
Description: The effects on lipid profiles of pharmacologic inhibition of ATP citrate lyase, an enzyme in the cholesterol–biosynthesis pathway upstream of HMGCR (the target of statins), are similar to those of statins. This inhibition may lower the risk of cardiovascular disease.
Publisher: United States: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
EISSN: 1533-4406
DOI: 10.1056/NEJMoa1806747
PMID: 30865797
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

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Mendelian Randomization Study of ACLY and Cardiovascular Disease

Copyright © 2019 Massachusetts Medical Society. All rights reserved. ;Copyright © 2019 Massachusetts Medical Society. ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1806747 ;PMID: 30865797

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