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Development of New Health Risk Assessment of Nanoparticles: EPA Health Risk Assessment Revised

Nanomaterials (Basel, Switzerland), 2022-12, Vol.13 (1), p.20 [Peer Reviewed Journal]

COPYRIGHT 2022 MDPI AG ;2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2022 by the authors. 2022 ;ISSN: 2079-4991 ;EISSN: 2079-4991 ;DOI: 10.3390/nano13010020 ;PMID: 36615930

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  • Title:
    Development of New Health Risk Assessment of Nanoparticles: EPA Health Risk Assessment Revised
  • Author: Macko, Michal ; Antoš, Jan ; Božek, František ; Konečný, Jiří ; Huzlík, Jiří ; Hegrová, Jitka ; Kuřitka, Ivo
  • Subjects: Air pollution ; Analysis ; Apoptosis ; Cadmium ; Cancer ; Case studies ; Health risk assessment ; Health risks ; Human body ; Methods ; Multipliers ; Nanoparticles ; Oxidative stress ; Risk assessment ; Size distribution ; Toxicity
  • Is Part Of: Nanomaterials (Basel, Switzerland), 2022-12, Vol.13 (1), p.20
  • Description: The concentration of nanoparticles in the ambient air can lead to induced toxicities; however, it appears that nanoparticles’ unique properties are completely omitted when assessing health risks. This paper aims to enhance the EPA health risk assessment by incorporating two new variables that consider the size of nanoparticles: the toxicity multiplier and the size multiplier. The former considers the qualitative aspect of the size of particles within a concentration, whilst the latter takes into account the effects associated with the number of particles of the specific i-th size distribution interval. To observe the impact of the new variables, a case study was performed. The studied element was cadmium, which was measured using ICP-MS to discover concentrations of size fractions, ranging from <15.1 to <9830 nm. Next, the cadmium concentration is assessed using both the current state-of-the-art method and the proposed method with adjustments. Based on the new approach, the final risk was 1.1 × 10−5, which was almost 24 times higher compared with the current method. The contribution of nanoparticles to the risk value grew from barely 6% to an alarming 88%. Therefore, the enhanced method can lead to more realistic results when assessing the health risks of nanoparticles.
  • Publisher: Switzerland: MDPI AG
  • Language: English
  • Identifier: ISSN: 2079-4991
    EISSN: 2079-4991
    DOI: 10.3390/nano13010020
    PMID: 36615930
  • Source: PubMed Central
    ROAD: Directory of Open Access Scholarly Resources
    ProQuest Central
    DOAJ Directory of Open Access Journals
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